2ky5: Difference between revisions

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-[[Image:2ky5.png|left|200px]]
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-The line below this paragraph, containing "STRUCTURE_2ky5", creates the "Structure Box" on the page.
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 {{STRUCTURE_2ky5|  PDB=2ky5  |  SCENE=  }}
 ===Solution structure of the PECAM-1 cytoplasmic tail with DPC===
+{{ABSTRACT_PUBMED_21464369}}
+==Function==
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+[[http://www.uniprot.org/uniprot/PECA1_HUMAN PECA1_HUMAN]] Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).<ref>PMID:12110892</ref> <ref>PMID:18388311</ref> <ref>PMID:19342684</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_21464369}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 21464369 is the PubMed ID number.
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-{{ABSTRACT_PUBMED_21464369}}
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:021464369</ref><references group="xtra"/>
+<ref group="xtra">PMID:021464369</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: CESG, Center for Eukaryotic Structural Genomics.]]