3qrr: Difference between revisions

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[[Image:3qrr.png|left|200px]]
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{{STRUCTURE_3qrr|  PDB=3qrr  |  SCENE=  }}  
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===Structure of Thermus Thermophilus Cse3 bound to an RNA representing a product complex===
===Structure of Thermus Thermophilus Cse3 bound to an RNA representing a product complex===
{{ABSTRACT_PUBMED_21572444}}


 
==Function==
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[[http://www.uniprot.org/uniprot/Q53WG9_THET8 Q53WG9_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product. Generates a 2',3'-cyclic phosphodiester.<ref>PMID:21572442</ref> <ref>PMID:21572444</ref>
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{{ABSTRACT_PUBMED_21572444}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:021572444</ref><references group="xtra"/>
<ref group="xtra">PMID:021572444</ref><references group="xtra"/><references/>
[[Category: Thermus thermophilus hb8]]
[[Category: Thermus thermophilus hb8]]
[[Category: E L., Garside.]]
[[Category: E L., Garside.]]

Revision as of 11:34, 8 May 2013

Template:STRUCTURE 3qrr

Structure of Thermus Thermophilus Cse3 bound to an RNA representing a product complexStructure of Thermus Thermophilus Cse3 bound to an RNA representing a product complex

Template:ABSTRACT PUBMED 21572444

FunctionFunction

[Q53WG9_THET8] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product. Generates a 2',3'-cyclic phosphodiester.[1] [2]

About this StructureAbout this Structure

3qrr is a 2 chain structure with sequence from Thermus thermophilus hb8. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Gesner EM, Schellenberg MJ, Garside EL, George MM, Macmillan AM. Recognition and maturation of effector RNAs in a CRISPR interference pathway. Nat Struct Mol Biol. 2011 May 15. PMID:21572444 doi:10.1038/nsmb.2042
  1. ↑ Sashital DG, Jinek M, Doudna JA. An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3. Nat Struct Mol Biol. 2011 Jun;18(6):680-7. Epub 2011 May 15. PMID:21572442 doi:10.1038/nsmb.2043
  2. ↑ Gesner EM, Schellenberg MJ, Garside EL, George MM, Macmillan AM. Recognition and maturation of effector RNAs in a CRISPR interference pathway. Nat Struct Mol Biol. 2011 May 15. PMID:21572444 doi:10.1038/nsmb.2042

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