2f9v: Difference between revisions
New page: left|200px<br /><applet load="2f9v" size="350" color="white" frame="true" align="right" spinBox="true" caption="2f9v, resolution 2.60Å" /> '''HCV NS3 protease dom... |
No edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
Depeptidization efforts of the P(3)-P(2) region of P(3) capped | Depeptidization efforts of the P(3)-P(2) region of P(3) capped alpha-ketoamide inhibitor of HCV NS3 serine protease 1 are reported. We clearly established that N-methylation of the P(2) nitrogen and modification of the P(2)' carboxylic acid terminus were essential for activity in the replicon assay. | ||
==About this Structure== | ==About this Structure== | ||
| Line 15: | Line 15: | ||
[[Category: Agrawal, S.]] | [[Category: Agrawal, S.]] | ||
[[Category: Baroudy, B.]] | [[Category: Baroudy, B.]] | ||
[[Category: Bogen, S | [[Category: Bogen, S L.]] | ||
[[Category: Girijavallabhan, V.]] | [[Category: Girijavallabhan, V.]] | ||
[[Category: Liu, R.]] | [[Category: Liu, R.]] | ||
[[Category: Njoroge, F | [[Category: Njoroge, F G.]] | ||
[[Category: Pichardo, J.]] | [[Category: Pichardo, J.]] | ||
[[Category: Prongay, A.]] | [[Category: Prongay, A.]] | ||
| Line 30: | Line 30: | ||
[[Category: ns3 protease]] | [[Category: ns3 protease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:19:18 2008'' | ||
Revision as of 18:19, 21 February 2008
|
HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines
OverviewOverview
Depeptidization efforts of the P(3)-P(2) region of P(3) capped alpha-ketoamide inhibitor of HCV NS3 serine protease 1 are reported. We clearly established that N-methylation of the P(2) nitrogen and modification of the P(2)' carboxylic acid terminus were essential for activity in the replicon assay.
About this StructureAbout this Structure
2F9V is a Protein complex structure of sequences from Hepatitis c virus with and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity., Bogen SL, Ruan S, Liu R, Agrawal S, Pichardo J, Prongay A, Baroudy B, Saksena AK, Girijavallabhan V, Njoroge FG, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1621-7. Epub 2006 Jan 4. PMID:16387495
Page seeded by OCA on Thu Feb 21 17:19:18 2008