2f9u: Difference between revisions
New page: left|200px<br /><applet load="2f9u" size="350" color="white" frame="true" align="right" spinBox="true" caption="2f9u, resolution 2.60Å" /> '''HCV NS3 protease dom... |
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==Overview== | ==Overview== | ||
Prolonged hepatitis C infection is the leading cause for cirrhosis of the | Prolonged hepatitis C infection is the leading cause for cirrhosis of the liver and hepatocellular carcinoma. The etiological agent HCV virus codes a single polyprotein of approximately 3000 amino acids that is processed with the help of a serine protease NS3A to produce structural and non-structural proteins required for viral replication. Inhibition of NS3 protease can potentially be used to develop drugs for treatment of HCV infections. Herein, we report the development of a series of novel NS3 serine protease inhibitors derived from 2-aza-bicyclo[2.2.1]-heptane carboxylic acid with potential therapeutic use for treatment of HCV infections. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Butkiewicz, N.]] | [[Category: Butkiewicz, N.]] | ||
[[Category: Girijavallabhan, V.]] | [[Category: Girijavallabhan, V.]] | ||
[[Category: Njoroge, F | [[Category: Njoroge, F G.]] | ||
[[Category: Pichardo, J.]] | [[Category: Pichardo, J.]] | ||
[[Category: Prongay, A | [[Category: Prongay, A J.]] | ||
[[Category: Venkatraman, S.]] | [[Category: Venkatraman, S.]] | ||
[[Category: Wu, W.]] | [[Category: Wu, W.]] | ||
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[[Category: ns3 protease]] | [[Category: ns3 protease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:19:12 2008'' | ||
Revision as of 18:19, 21 February 2008
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HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane
OverviewOverview
Prolonged hepatitis C infection is the leading cause for cirrhosis of the liver and hepatocellular carcinoma. The etiological agent HCV virus codes a single polyprotein of approximately 3000 amino acids that is processed with the help of a serine protease NS3A to produce structural and non-structural proteins required for viral replication. Inhibition of NS3 protease can potentially be used to develop drugs for treatment of HCV infections. Herein, we report the development of a series of novel NS3 serine protease inhibitors derived from 2-aza-bicyclo[2.2.1]-heptane carboxylic acid with potential therapeutic use for treatment of HCV infections.
About this StructureAbout this Structure
2F9U is a Protein complex structure of sequences from Hepatitis c virus with and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid., Venkatraman S, Njoroge FG, Wu W, Girijavallabhan V, Prongay AJ, Butkiewicz N, Pichardo J, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1628-32. Epub 2006 Jan 18. PMID:16413182
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