Aspartate-semialdehyde dehydrogenase: Difference between revisions
New page: left|200px|thumb|Crystal Structure of Aspartate-semialdehyde dehydrogenase, [[1mc4]] {{STRUCTURE_1mc4| PDB=1mc4 | SIZE=300| SCENE= |right|CAPTION=Aspartate-semialdehyd... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1mc4.png|left|200px|thumb|Crystal Structure of Aspartate-semialdehyde dehydrogenase, [[1mc4]]]] | [[Image:1mc4.png|left|200px|thumb|Crystal Structure of Aspartate-semialdehyde dehydrogenase, [[1mc4]]]] | ||
{{STRUCTURE_1mc4| PDB=1mc4 | SIZE=300| SCENE= |right|CAPTION=Aspartate-semialdehyde dehydrogenase, [[1mc4]] }} | {{STRUCTURE_1mc4| PDB=1mc4 | SIZE=300| SCENE= |right|CAPTION=Aspartate-semialdehyde dehydrogenase, [[1mc4]] }} | ||
[[Aspartate-semialdehyde dehydrogenase]] (ASADH) is an enzyme which is part of the biosynthesis of amino acids. It catalyzes the conversion of L-aspartate 4-semialdehyde (ASA) + phosphate + NADP to L-4-aspartyl phosphate + NADPH + H+. The images at the left and at the right correspond to one representative ASADH, ''i.e.'' the crystal structure of Aspartate-semialdehyde dehydrogenase from ''Vibrio cholerae'' ([[1mc4]]). | |||
{{TOC limit|limit=2}} | |||
<br /> | |||
<br /> | |||
<br /> | |||
<br /> | |||
<br /> | |||
== 3D Structures of Aspartate-semialdehyde dehydrogenase == | |||
[[2qz9]], [[1mc4]] – VcASADH II – ''Vibrio cholerae''<br /> | |||
[[2yv3]] – ASADH – ''Thermus thermiphilus''<br /> | |||
[[1t4d]], [[1t4b]], [[1brm]] - EcASADH β - ''Escherichia coli''<br /> | |||
[[1pu2]], [[1oza]] - HiASADH (mutant) – ''Haemophilus influenzae''<br /> | |||
[[1nwc]] – HiASADH<br /> | |||
[[1nwh]] – HiASADH reaction intermediate<br /> | |||
===ASADH binary complex=== | |||
[[2r00]] - VcASADH II + ASA<br /> | |||
[[3llg]] – ASADH + glycerot + Pi – ''Mycobacterium tuberculosis''<br /> | |||
[[3hsk]] – ASADH + NADP – ''Candida albicans''<br /> | |||
[[1ys4]] - ASADH + NADP – ''Methanocaldococcus jannaschii''<br /> | |||
[[1nx6]] - HiASADH reaction intermediate +Pi<br /> | |||
[[1ta4]] - HiASADH + As<br /> | |||
[[1tb4]] - HiASADH + IO4<br /> | |||
[[1q2x]] - HiASADH (mutant) + ASA<br /> | |||
===ASADH ternary complex=== | |||
[[1pqu]] - HiASADH (mutant) + NADP + cacodylate + substrate analog<br /> | |||
[[1pqp]] - HiASADH (mutant) + ASA + Pi<br /> | |||
[[1gl3]] - EcASADH β + NADP + substrate analog<br /> | |||
[[1mb4]] - VcASADH + NADP + substrate analog<br /> | |||
[[Category:Topic Page]] | |||
