Hexokinase: Difference between revisions
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-Hexokinase IV/D is also known as glucokinase. | -Hexokinase IV/D is also known as glucokinase. | ||
{{STRUCTURE_1hkc | PDB=1hkc | | {{STRUCTURE_1hkc| PDB=1hkc | SIZE=300| SCENE= |right| CAPTION=Human hexokinase 1 complex with glucose and phosphate, [[1hkc]] }} | ||
== Structure of Hexokinase == | == Structure of Hexokinase == | ||
Hexokinase is composed of an N-terminal regulatory domain and a C-terminal catalytic domain. These two domains are <scene name='Bawel_sandbox1/Hexokinase/2'>joined together by an alpha helix</scene>. The molecular weights of hexokinases are around 100 kD. Each domain weighs about 50kD and contains a <scene name='Bawel_sandbox1/Glucose_binding_site/1'>glucose binding site</scene>. But, only in hexokinase II do both halves have functional active sites. The tertiary structure of hexokinase includes an open alpha/beta sheet. There is a large amount of variation associated with this structure. The ATP-binding domain is composed of <scene name='Bawel_sandbox1/5_beta_sheets/3'>five beta sheets and two alpha helices</scene>. In this open alph/beta sheet four of the beta sheets are parallel and one is in the anitparallel directions. The alpha helices and beta loops connect the beta sheets to produce this open alpha/beta sheet. | Hexokinase is composed of an N-terminal regulatory domain and a C-terminal catalytic domain. These two domains are <scene name='Bawel_sandbox1/Hexokinase/2'>joined together by an alpha helix</scene>. The molecular weights of hexokinases are around 100 kD. Each domain weighs about 50kD and contains a <scene name='Bawel_sandbox1/Glucose_binding_site/1'>glucose binding site</scene>. But, only in hexokinase II do both halves have functional active sites. The tertiary structure of hexokinase includes an open alpha/beta sheet. There is a large amount of variation associated with this structure. The ATP-binding domain is composed of <scene name='Bawel_sandbox1/5_beta_sheets/3'>five beta sheets and two alpha helices</scene>. In this open alph/beta sheet four of the beta sheets are parallel and one is in the anitparallel directions. The alpha helices and beta loops connect the beta sheets to produce this open alpha/beta sheet. | ||