2dxs: Difference between revisions

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 ==Overview==
-We report a new series of hepatitis C virus NS5B RNA polymerase inhibitors, containing a conformationally constrained tetracyclic scaffold. SAR, studies led to the identification of, 6,7-dihydro-5H-benzo[5,6][1,4]diazepino[7,1-a]indoles (19 and 20) bearing, a basic pendent group with high biochemical and cellular potencies. These, compounds displayed a very small shift in cellular potency when the, replicon assay was performed in the presence of human serum albumin.
+We report a new series of hepatitis C virus NS5B RNA polymerase inhibitors containing a conformationally constrained tetracyclic scaffold. SAR studies led to the identification of 6,7-dihydro-5H-benzo[5,6][1,4]diazepino[7,1-a]indoles (19 and 20) bearing a basic pendent group with high biochemical and cellular potencies. These compounds displayed a very small shift in cellular potency when the replicon assay was performed in the presence of human serum albumin.
 ==About this Structure==
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 [[Category: rna polymerase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:14:22 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:03:49 2008''