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2xae: Difference between revisions

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[[Image:2xae.png|left|200px]]
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{{STRUCTURE_2xae|  PDB=2xae  |  SCENE=  }}  
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===CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID===
===CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID===
{{ABSTRACT_PUBMED_21344920}}


==Disease==
[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_21344920}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 21344920 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21344920}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:021344920</ref><references group="xtra"/>
<ref group="xtra">PMID:021344920</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Joseph, B.]]
[[Category: Joseph, B.]]
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[[Category: Ulaganathan, V.]]
[[Category: Ulaganathan, V.]]
[[Category: Weiss, J.]]
[[Category: Weiss, J.]]
[[Category: Cell cycle]]
[[Category: Ksp]]
[[Category: Mitosis]]

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