Sandbox SouthUniversity1: Difference between revisions
Arthur Cox (talk | contribs) No edit summary |
Arthur Cox (talk | contribs) No edit summary |
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'''Turn off''' (toggle) '''spinning''' of the protein by clicking on the button below the structure. The quality of the molecule rendering can also be increased by clicking the '''"toggle quality"''' button, although this may decrease the smoothness when the molecule is rotating. | '''Turn off''' (toggle) '''spinning''' of the protein by clicking on the button below the structure. The quality of the molecule rendering can also be increased by clicking the '''"toggle quality"''' button, although this may decrease the smoothness when the molecule is rotating. | ||
Now '''rotate''' the molecule by clicking and dragging in the window with your cursor. '''Resize''' the molecule by holding down the shift key and dragging up and down. Rotate and resize the molecule until you can clearly see that there are 2 molecules shown in a "space-filling" representation in the middle of the protein. These are a heme molecule, which is absolutely vital for the enzyme's function, and a second molecule (alpha-naphthoflavone) which represents a drug that is about to be metabolized. | Now '''rotate''' the molecule by clicking and dragging in the window with your cursor. '''Resize''' the molecule by holding down the shift key and dragging up and down. Rotate and resize the molecule until you can clearly see that there are 2 molecules shown in a "space-filling" representation in the middle of the protein (they are more or less perpendicular to each other). These are a heme molecule, which is absolutely vital for the enzyme's function, and a second molecule (alpha-naphthoflavone) which represents a drug that is about to be metabolized. | ||
First, lets look at the heme. Click the following link to hide the rest of the protein and <scene name='Sandbox_SouthUniversity1/Heme_only/1'>highlight the heme ring system.</scene> Carbon atoms are shown in grey, Nitrogen atoms are blue, Oxygen is red, and the central iron atom is orange. The iron atom is the vital center that does the actual oxidation of substrates (drugs or other xenobiotics). It is highlighted <scene name='Sandbox_SouthUniversity1/Heme_sticks_fe_ball/1'>here.</scene> | First, lets look at the heme. Click the following link to hide the rest of the protein and <scene name='Sandbox_SouthUniversity1/Heme_only/1'>highlight the heme ring system.</scene> Carbon atoms are shown in grey, Nitrogen atoms are blue, Oxygen is red, and the central iron atom is orange. The iron atom is the vital center that does the actual oxidation of substrates (drugs or other xenobiotics). It is highlighted <scene name='Sandbox_SouthUniversity1/Heme_sticks_fe_ball/1'>here.</scene> | ||