Bacterial Replication Termination: Difference between revisions

<StructureSection load='1f4k' size='500' side='right' caption='The Replication Terminator Protein (RTP) complexed to it's ''ter'' site' scene='User:Bianca_Varney/Bacterial_Replication_Termination/Opening_rtp/1'>Replication Termination Protein (RTP), found in ''Bacillus subtilis'', is a member of the ‘winged helix’ protein family, and terminates bacterial DNA replication by arresting the replication forks through interactions with DNA in a sequence specific manner [7]. RTP blocks the replication fork through contrahelicase activity; the ability to specifically inhibit the helicase replication machinery and has an additional role in arresting transcription [1][2]. In ''B. subtilis'' the bipartite ''ter'' sequence is overlapping, and each inverted repeat contains core (IRIB) and an auxillary (IRIA) sites [1]. RTP binds to these sequences, resulting in the impediment the replication fork helicase.