2afv: Difference between revisions
New page: left|200px<br /><applet load="2afv" size="350" color="white" frame="true" align="right" spinBox="true" caption="2afv, resolution 3.00Å" /> '''The Crystal Structur... |
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==Overview== | ==Overview== | ||
The leptospira cbiC encodes the enzyme catalyzing the methyl rearrangement | The leptospira cbiC encodes the enzyme catalyzing the methyl rearrangement reaction of the cobalamin biosynthesis pathway. The protein has been cloned and overexpressed as a His-tagged recombinant protein in Escherichia coli. The crystal structures have been solved in two crystal forms (P4(2)2(1)2 and P3(1)21) diffracting to 3.0 and 2.3A resolution, respectively. The structures are similar to the precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: isomerase]] | [[Category: isomerase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:26:58 2008'' | ||
Revision as of 17:26, 21 February 2008
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The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis
OverviewOverview
The leptospira cbiC encodes the enzyme catalyzing the methyl rearrangement reaction of the cobalamin biosynthesis pathway. The protein has been cloned and overexpressed as a His-tagged recombinant protein in Escherichia coli. The crystal structures have been solved in two crystal forms (P4(2)2(1)2 and P3(1)21) diffracting to 3.0 and 2.3A resolution, respectively. The structures are similar to the precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12.
About this StructureAbout this Structure
2AFV is a Single protein structure of sequence from Leptospira interrogans with , and as ligands. Active as Precorrin-8X methylmutase, with EC number 5.4.1.2 Full crystallographic information is available from OCA.
ReferenceReference
The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis., Xue Y, Wei Z, Li X, Gong W, J Struct Biol. 2006 Mar;153(3):307-11. Epub 2005 Dec 27. PMID:16427313
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