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Hexokinase activates glycoloysis by phosphorylating glucose. Since the phosphorylation of glucose to glucose-6-phosphate is the rate limiting step of glucose metabolism, hexokinase has a very important job in regulating healthy glucose levels in the human body [7]. Hexokinase has high affinity, thus a low Km, for glucose. Tisssues where hexokinase is present use glucose at low blood serum levels. | Hexokinase activates glycoloysis by phosphorylating glucose. Since the phosphorylation of glucose to glucose-6-phosphate is the rate limiting step of glucose metabolism, hexokinase has a very important job in regulating healthy glucose levels in the human body [7]. Hexokinase has high affinity, thus a low Km, for glucose. Tisssues where hexokinase is present use glucose at low blood serum levels. | ||
G6P inhibits hexokinase by binding to the N-terminal domain(this is simple feedback inhibition). If the cell is not using the G6P that it is making, then it stops making it. In this way, hexokinase can also slow down glycolysis. Hexokinase I is thought to be the "pacemaker of glycolysis in brain tissue and red blood cells [4]. Inorganic phosphate allosterically relieves hexokinase I of inhibition by G6P [8]. | G6P inhibits hexokinase by binding to the N-terminal domain(this is simple feedback inhibition). If the cell is not using the G6P that it is making, then it stops making it. In this way, hexokinase can also slow down glycolysis. Hexokinase I is thought to be the "pacemaker of glycolysis in brain tissue and red blood cells [4]. Inorganic phosphate allosterically relieves hexokinase I of inhibition by G6P [8]. | ||
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7.↑ Pal P, and Miller B. Activating Mutations in the Human Glucokinase Gene Revealed by Genetic Selection. Biochem. 2008 Dec 3;48:814-816. | 7.↑ Pal P, and Miller B. Activating Mutations in the Human Glucokinase Gene Revealed by Genetic Selection. Biochem. 2008 Dec 3;48:814-816. | ||
8.↑ Aleshin A, Malfois M, Liu X, Kim C, Fromm H, Honzatko R, Koch M, Svergun D. Nonaggregating Mutant of Recombinant Human Hexokinase I Exhibits Wild-Type Kinetics and Rod-like Conformations in Solution. Biochem. 1999 Apr 29;38:8359-8366. | |||
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