Evans sandbox 1: Difference between revisions
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E3 is common to all a-ketoacid dehydrogenase complexes. Errors in the gene coding human E3 cause combined deficiencies in a-ketoacid dehydrogenase complexes manifested by lactic acidemias and Maple Syrup Urine Disease[http://en.wikipedia.org/wiki/Maple_syrup_urine_disease]. A subset of the human E3 mutations has been suggested to occur at the homodimer interface or at the putative E3/E3BP interaction surface | E3 is common to all a-ketoacid dehydrogenase complexes. Errors in the gene coding human E3 cause combined deficiencies in a-ketoacid dehydrogenase complexes manifested by lactic acidemias and Maple Syrup Urine Disease[http://en.wikipedia.org/wiki/Maple_syrup_urine_disease]. A subset of the human E3 mutations has been suggested to occur at the homodimer interface or at the putative E3/E3BP interaction surface | ||
[[Image: pyruvate_dehydrogenase.gif| | [[Image: pyruvate_dehydrogenase.gif|500px|left|thumb]] | ||
[[Image: PyruvateDehydrgenaseMech1.gif| | [[Image: PyruvateDehydrgenaseMech1.gif|500px|left|thumb]] | ||
==Structure== | ==Structure== | ||