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-Hexokinase IV/D is also known as glucokinase and is described below. | -Hexokinase IV/D is also known as glucokinase and is described below. | ||
{{STRUCTURE_1hkc | PDB=1hkc | SCENE= }} | |||
Hexokinase Structure: | Hexokinase Structure: | ||
The tertiary structure of hexokinase includes an open alpha/beta sheet. There is a large amount of variation associated with this structure. The ATP-binding domain is composed of five beta sheets and three alpha helices. In this open alph/beta sheet four of the beta sheets are parallel and one is in the anitparallel directions. The alpha helices and beta loops connect the beta sheets to produce this open alpha/beta sheet. The crevice indicates the ATP-binding domain of this glycolytic enzyme. The molecular weights of hexokinases are around 100 kD. Each consists of two similar 50kD halves, but only in hexokinase II do both halves have functional active sites. | The tertiary structure of hexokinase includes an open alpha/beta sheet. There is a large amount of variation associated with this structure. The ATP-binding domain is composed of five beta sheets and three alpha helices. In this open alph/beta sheet four of the beta sheets are parallel and one is in the anitparallel directions. The alpha helices and beta loops connect the beta sheets to produce this open alpha/beta sheet. The crevice indicates the ATP-binding domain of this glycolytic enzyme. The molecular weights of hexokinases are around 100 kD. Each consists of two similar 50kD halves, but only in hexokinase II do both halves have functional active sites. | ||
[[Image:Hexokinase_mechanism2.GIF|350px|left|thumb]] | [[Image:Hexokinase_mechanism2.GIF|350px|left|thumb]] | ||