1agj: Difference between revisions
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Revision as of 15:43, 30 October 2007
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EPIDERMOLYTIC TOXIN A FROM STAPHYLOCOCCUS AUREUS
OverviewOverview
BACKGROUND: Staphylococcal epidermolytic toxins A and B (ETA and ETB) are, responsible for the staphylococcal scalded skin syndrome of newborn and, young infants; this condition can appear just a few hours after birth., These toxins cause the disorganization and disruption of the region, between the stratum spinosum and the stratum granulosum--two of the three, cellular layers constituting the epidermis. The physiological substrate of, ETA is not known and, consequently, its mode of action in vivo remains an, unanswered question. Determination of the structure of ETA and its, comparison with other serine proteases may reveal insights into ETA's, catalytic mechanism. RESULTS: The crystal structure of staphylococcal ETA, has been determined by multiple isomorphous replacement and refined at ... [(full description)]
About this StructureAbout this Structure
1AGJ is a [Single protein] structure of sequence from [Staphylococcus aureus]. Structure known Active Sites: SNA and SNB. Full crystallographic information is available from [OCA].
ReferenceReference
The structure of Staphylococcus aureus epidermolytic toxin A, an atypic serine protease, at 1.7 A resolution., Cavarelli J, Prevost G, Bourguet W, Moulinier L, Chevrier B, Delagoutte B, Bilwes A, Mourey L, Rifai S, Piemont Y, Moras D, Structure. 1997 Jun 15;5(6):813-24. PMID:9261066
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