Sandbox Reserved 327: Difference between revisions
| Line 14: | Line 14: | ||
on one side with N-terminal tail (aa 1-23) or NTT <ref name="eIF1"/>. It is homolog to | on one side with N-terminal tail (aa 1-23) or NTT <ref name="eIF1"/>. It is homolog to | ||
<scene name='Sandbox_Reserved_327/Human_eif1/1'>human eIF1</scene> | <scene name='Sandbox_Reserved_327/Human_eif1/1'>human eIF1</scene> | ||
since it has 87% structure similarity and 63% identity (DNA sequence) to the human eIF1 <ref name="eIF1"/> <ref name="flet"/>. However, yeast eIF1 has two different conformations with two clear sets of backbone resonances that interconverting with each other and 20 different possible models for the N-terminal tail structure <ref name="eIF1"/>. So far, the binding sites of eIF1 to ribosome and eIF5 have been determined, while the exact | since it has 87% structure similarity and 63% identity (DNA sequence) to the human eIF1 <ref name="eIF1"/> <ref name="flet"/>. However, yeast eIF1 has two different conformations with two clear sets of backbone resonances that interconverting with each other and 20 different possible models for the N-terminal tail structure <ref name="eIF1"/>. So far, only the binding sites of eIF1 to ribosome and eIF5 have been determined, while the exact binding site interactions with other initiation proteins are still unknown <ref name="eIF1"/> <ref name="flet"/>. | ||
==eIF1-ribosome binding site== | ==eIF1-ribosome binding site== | ||