Sandbox Reserved 327: Difference between revisions
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[[Image:640px-Eukaryotic_initiation.png|thumb|left|Mechanism of Eukaryotic initiation]] | [[Image:640px-Eukaryotic_initiation.png|thumb|left|Mechanism of Eukaryotic initiation]] | ||
==Structure== | ==Structure== | ||
eIF1 is one of | eIF1 is a small protein (12 kDa) that is encode by ''sui1'' which is one of the component of multifactor complex (MFC) that plays an important role in regulating translation initiation <ref name="asano"/><ref name="eIF1"/>. eIF1 is a universal translation factor across organisms which make eIF1 homologs can be found in other eukayotes, archaea, and some bacteria <ref name="structure"/>. Yeast eIF1 contains a | ||
<scene name='Sandbox_Reserved_327/Ribbon_structure/1'>β-sheet with α helices</scene> | |||
<scene name='Sandbox_Reserved_327/Ribbon_structure/1'> | on one side with N-terminal tail (aa 1-23) or NTT <ref name="eIF1"/>. It is homolog to human eIF1 since the structure is similar to human eIF1 (87%) with 63% matched DNA composition (identity) <ref name="structure"/> <ref name="eIF1"/>. However, yeast eIF1 has two different conformations with two clear sets of backbone resonances for 13 of the 20 residues that lead to 20 different possible solution structure of yeast eIF1 <ref name="eIF1"/>. | ||
==Function== | ==Function== | ||
*regulator of start site selection | *regulator of start site selection | ||
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<ref name="eIF1"> PMID:17974565 </ref> | <ref name="eIF1"> PMID:17974565 </ref> | ||
<ref name="eIF1A"> DOI 10.1016/j.molcel.2007.03.018 </ref> | <ref name="eIF1A"> DOI 10.1016/j.molcel.2007.03.018 </ref> | ||
<ref name=" | <ref name="1999"> PMID: 10228174 </ref> | ||
<ref name=" | <ref name="asano"> DOI:10.1101/gad.1562707 </ref> | ||
<ref name="elegans"> DOI:10.1534/genetics.110.121541 </ref> | <ref name="elegans"> DOI:10.1534/genetics.110.121541 </ref> | ||
<references/> | <references/> | ||