Prp24: Difference between revisions
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== Structure == | == Structure == | ||
<Structure load='2ghp' size='300' frame='true' align='right' caption='X-ray crystallographic structure of the first three RRMs of Prp24' scene='Sandbox_Reserved_340/2ghp/3'> | <Structure load='2ghp' size='300' frame='true' align='right' caption='X-ray crystallographic structure of the first three RRMs of Prp24' scene='Sandbox_Reserved_340/2ghp/3'/> | ||
The key structural elements of Prp24 are the conserved RNA recognition motifs (RRMs). These motifs are found in many proteins with RNA binding properties and contain conserved RNP elements that are recognizable by their primary sequence <ref name="Shannon"/>. For several years, Prp24 was thought to contain three RRMs, termed RRM 1, RRM 2, and RRM 3 (green link)<ref name="Shannon"/>. However, analysis of homologs of Prp24 from several different species allowed the identification of a fourth RRM in Prp24 of ''S. cerevisiae'', albeit one that was much less highly conserved and not easily recognizable by its RNP-consensus domain <ref name="Rader"/>. | The key structural elements of Prp24 are the conserved RNA recognition motifs (RRMs). These motifs are found in many proteins with RNA binding properties and contain conserved RNP elements that are recognizable by their primary sequence <ref name="Shannon"/>. For several years, Prp24 was thought to contain three RRMs, termed RRM 1, RRM 2, and RRM 3 (green link)<ref name="Shannon"/>. However, analysis of homologs of Prp24 from several different species allowed the identification of a fourth RRM in Prp24 of ''S. cerevisiae'', albeit one that was much less highly conserved and not easily recognizable by its RNP-consensus domain <ref name="Rader"/>. | ||
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== Functional Interactions == | == Functional Interactions == | ||
<Structure load='2ghp' size='300' frame='true' align='right' caption='Insert caption here' scene=' | <Structure load='2ghp' size='300' frame='true' align='right' caption='Insert caption here' scene='Sandbox_Reserved_340/2ghp/3'/> | ||
Prp24 is part of the normal U6 snRNP, along with seven Lsm proteins <ref name="Brow review"/>. After interaction with the U4 snRNP to form the U4/U6 di-snRNP, Prp24 departs from the di-snRNP before the addition of U5 to form the tri-snRNP U4/U6.U5 <ref name="Brow review"/>. Through many studies, it has been shown that Prp24 interacts extensively with specific sites on U6, as well with the Lsm protein ring on the 3' terminal end of the U6 snRNA. | Prp24 is part of the normal U6 snRNP, along with seven Lsm proteins <ref name="Brow review"/>. After interaction with the U4 snRNP to form the U4/U6 di-snRNP, Prp24 departs from the di-snRNP before the addition of U5 to form the tri-snRNP U4/U6.U5 <ref name="Brow review"/>. Through many studies, it has been shown that Prp24 interacts extensively with specific sites on U6, as well with the Lsm protein ring on the 3' terminal end of the U6 snRNA. | ||