Sandbox Reserved 167: Difference between revisions
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== Future Importance of P16INK4a == | == Future Importance of P16INK4a == | ||
P16INK4a has been discovered to be an important biological marker for the presence of high-rish Human Papillomavirus in patients because of its over-expression due to the disruption of the binding mechanism between the transcription factor E2F and pRB.<ref name="Silverman"> Silverman, Robert, RPh, MM and Ridder, Dr. Rüdiger. p16INK4a Antibody. MTM Laboratories Website. http://mtmlabs.com/us/index.php/science-a-technology/p16ink4a </ref>. | P16INK4a has been discovered to be an important biological marker for the presence of high-rish Human Papillomavirus in patients because of its over-expression due to the disruption of the binding mechanism between the transcription factor E2F and pRB.<ref name="Silverman"> Silverman, Robert, RPh, MM and Ridder, Dr. Rüdiger. p16INK4a Antibody. MTM Laboratories Website. http://mtmlabs.com/us/index.php/science-a-technology/p16ink4a </ref>. P16INK4a is an independent factor from the HR-HPV type and therefore can be used to detect the presence of cervical cancer disease when tested for among HR-HPV and non-HPV patients.<ref name="Byeon"> Byeon, I.J., Li, J., Ericson, K., Selby, T.L., Tevelev, A., Kim, H.J., O`Maille, P., Tsai, M.D. Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4.(1998) Mol.Cell 1: 421-431 PMID: 9660926 </ref>. Oncogenic activity among all types of HPV patients can be identified with the blocking of pRB by E7 and the over-expression of p16INK4a caused by this inhibition. Testing for the presence of the over-expression of p16INK4a in pre-cancerous and cancerous individuals is easy and efficient and has become increasingly used among doctors alike. | ||
== References == | == References == | ||
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