Sandbox Reserved 327: Difference between revisions
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{{Template:Sandbox_Reserved_BCMB307}} | {{Template:Sandbox_Reserved_BCMB307}} | ||
<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | <!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
Yeast eIF1 | |||
=Introduction= | =Introduction= | ||
[[Image:640px-Eukaryotic_initiation.png|thumb|left|Mechanism of Eukaryotic initiation]] | [[Image:640px-Eukaryotic_initiation.png|thumb|left|Mechanism of Eukaryotic initiation]] | ||
Translation is an essential process for both prokaryotes and eukaryotes to make various proteins from nucleic acid. It requires three different steps: initiation, elongation, and termination. Many proteins are needed in the initiation phase to form an initiation complex with the ribosome and promote the translation. In eukaryotes, these proteins are also known as eukaryotic initiation factors (eIF). The eIFs were first studied through the genetic analyzed of yeast ''Saccharomyces cerevisiae'' <ref name="elegans"/>. The initiation process is complex since it involves at least 12 eIFs containing more than 30 polypeptides , including eIF1, eIF2, eIF3, eIF4, and eIF5 <ref name="elegans"/>. | Translation is an essential process for both prokaryotes and eukaryotes to make various proteins from nucleic acid. It requires three different steps: initiation, elongation, and termination. Many proteins are needed in the initiation phase to form an initiation complex with the ribosome and promote the translation. In eukaryotes, these proteins are also known as eukaryotic initiation factors (eIF). The eIFs were first studied through the genetic analyzed of yeast ''Saccharomyces cerevisiae'' <ref name="elegans"/>. The initiation process is complex since it involves at least 12 eIFs containing more than 30 polypeptides , including eIF1, eIF2, eIF3, eIF4, and eIF5 <ref name="elegans"/>. | ||
{{STRUCTURE_2ogh|PDB=2ogh|SCENE}} | {{STRUCTURE_2ogh|PDB=2ogh|SCENE}} | ||
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how its bind | how its bind | ||
*possible green link: show binding region of eIF1 to the eIF5 --> surface representation | *possible green link: show binding region of eIF1 to the eIF5 --> surface representation | ||
<scene name='Sandbox_Reserved_327/Basic_eif1/3'>binding site</scene> | <scene name='Sandbox_Reserved_327/Basic_eif1/3'>eIF5 binding site</scene> | ||