Sandbox reserved 193: Difference between revisions
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=='''Acid Base Catalysis by RNase A'''== | =='''Acid Base Catalysis by RNase A'''== | ||
In the acid base catalysis of RNA in mammalians, RNase A catalyzes the cleavage of the P-O 5’ bond, and is comprised of two separate processes, the formation of … and subsequent… An important part of the reaction is Histidine’s ability to both accept and donate electrons. This acts as a proton source, allowing Histidine to be utilized as a base or acid, making the reaction pH dependent. | In the acid base catalysis of RNA in mammalians, RNase A catalyzes the cleavage of the P-O 5’ bond, and is comprised of two separate processes, the formation of … and subsequent… An important part of the reaction is Histidine’s ability to both accept and donate electrons. This acts as a proton source, allowing Histidine to be utilized as a base or acid, making the reaction pH dependent. | ||
[[Image:mech3.png|500px|left|thumb|Figure I: RNase A Catalysis]] | |||
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<Structure load='5rsa' size='250' frame='true' align='right' caption='Ribonuclease A' scene='Mechanism' /> | <Structure load='5rsa' size='250' frame='true' align='right' caption='Ribonuclease A' scene='Mechanism' /> | ||