Plasmepsin: Difference between revisions
New page: left|thumb|300px|Crystal Strcture of the Plasmepsin, [[3fns]] {{STRUCTURE_3fns| right| PDB=3fns | SCENE= |CAPTION=Plasmepsin, 3fns }} Plasmepsin (Plm) is a he... |
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[[Image:3fns.jpg|left|thumb|300px|Crystal Strcture of the Plasmepsin, [[3fns]]]] | [[Image:3fns.jpg|left|thumb|300px|Crystal Strcture of the Plasmepsin, [[3fns]]]] | ||
{{STRUCTURE_3fns| right| PDB=3fns | SCENE= |CAPTION=Plasmepsin, [[3fns]] }} | {{STRUCTURE_3fns| right| PDB=3fns | SCENE= |CAPTION=Plasmepsin witn Zn ions, [[3fns]] }} | ||
[[Plasmepsin]] (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is a potential target for anti-malaria drugs. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP). ProPml II exhibits a large shift between its domains which renders the protease inactive. The images on the left and right correspond to one representative Plm structure, ''i.e.'' the Plasmepsin from ''Plasmodium falciparum'' ([[3fns]]). | [[Plasmepsin]] (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is a potential target for anti-malaria drugs. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP). ProPml II exhibits a large shift between its domains which renders the protease inactive. The images on the left and right correspond to one representative Plm structure, ''i.e.'' the Plasmepsin from ''Plasmodium falciparum'' ([[3fns]]). | ||
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''Update June 2011'' | |||
===HAP=== | ===HAP=== | ||
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[[3fnt]] – PfHAP + inhibitor pepstatin<br /> | [[3fnt]] – PfHAP + inhibitor pepstatin<br /> | ||
[[3fnu]] – PfHAP + KNI-10006<br /> | [[3fnu]] – PfHAP + KNI-10006<br /> | ||
===Plm I=== | |||
[[3qrv]] – PfPlm I residues 117-457<br /> | |||
[[3qs1]] - PfPlm I residues 117-457 + inhibitor | |||
===Plm II=== | ===Plm II=== | ||
