3lsx: Difference between revisions
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{{STRUCTURE_3lsx| PDB=3lsx | SCENE= }} | {{STRUCTURE_3lsx| PDB=3lsx | SCENE= }} | ||
===Piracetam bound to the ligand binding domain of GluA3=== | ===Piracetam bound to the ligand binding domain of GluA3=== | ||
{{ABSTRACT_PUBMED_20163115}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[3lsx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus | [[3lsx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LSX OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020163115</ref><references group="xtra"/><references/> | ||
[[Category: Rattus norvegicus | [[Category: Rattus norvegicus]] | ||
[[Category: Ahmed, A H.]] | [[Category: Ahmed, A H.]] | ||
[[Category: Oswald, R E.]] | [[Category: Oswald, R E.]] | ||
[[Category: Allosteric modulator]] | |||
[[Category: Ampa receptor]] | |||
[[Category: Glua3]] | |||
[[Category: Glur3]] | |||
[[Category: Glutamate receptor]] | |||
[[Category: Neurotransmitter receptor]] | |||
[[Category: S1s2]] | |||
[[Category: Transport protein]] | |||
Revision as of 02:07, 11 April 2013
Piracetam bound to the ligand binding domain of GluA3Piracetam bound to the ligand binding domain of GluA3
Template:ABSTRACT PUBMED 20163115
FunctionFunction
[GRIA3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
About this StructureAbout this Structure
3lsx is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Ahmed AH, Oswald RE. Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors. J Med Chem. 2010 Mar 11;53(5):2197-203. PMID:20163115 doi:10.1021/jm901905j