Sandbox 80: Difference between revisions
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This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The <scene name='Sandbox_80/Protease/1'>protease</scene> is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. | This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The <scene name='Sandbox_80/Protease/1'>protease</scene> is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses. | ||
The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to <scene name='Sandbox_80/Ac_1/1'>active site 1</scene> of the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles. | The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to <scene name='Sandbox_80/Ac_1/1'>active site 1</scene> of the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles. This drug is often used in combination with other HIV medications to produce a more potent effect. | ||
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==Protein and Drug interations== | ==Protein and Drug interations== | ||
intermolecular forces that cause the drug to bind in the active site of the protease are prodominantly H-bonds to | intermolecular forces that cause the drug to bind in the active site of the protease are prodominantly H-bonds to | ||
<scene name='Sandbox_80/Hydrophilic/1'>hydrophilic groups</scene> | <scene name='Sandbox_80/Hydrophilic/1'>hydrophilic groups</scene>. The carboxylic acid group in the <scene name='Sandbox_80/Asp_25/1'>Aspartic Acid</scene> residue 25 binds with the hydroxyl group of Saquinavir. | ||
==References== | ==References== | ||
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973 | http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973 | ||
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction | http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction | ||