2xwt: Difference between revisions

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[[Image:2xwt.jpg|left|200px]]
[[Image:2xwt.png|left|200px]]


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===CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A BLOCKING TYPE TSHR AUTOANTIBODY===
===CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A BLOCKING TYPE TSHR AUTOANTIBODY===


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==Reference==
==Reference==
<ref group="xtra">PMID:21247981</ref><ref group="xtra">PMID:17542669</ref><ref group="xtra">PMID:19530271</ref><ref group="xtra">PMID:12867115</ref><ref group="xtra">PMID:15320966</ref><ref group="xtra">PMID:19221175</ref><ref group="xtra">PMID:17199429</ref><ref group="xtra">PMID:17725428</ref><ref group="xtra">PMID:18606720</ref><references group="xtra"/>
<ref group="xtra">PMID:021247981</ref><ref group="xtra">PMID:017542669</ref><ref group="xtra">PMID:019530271</ref><ref group="xtra">PMID:015320966</ref><ref group="xtra">PMID:019221175</ref><ref group="xtra">PMID:017199429</ref><ref group="xtra">PMID:017725428</ref><ref group="xtra">PMID:018606720</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Baker, S.]]
[[Category: Baker, S.]]
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[[Category: Wilmot, J.]]
[[Category: Wilmot, J.]]
[[Category: Young, S.]]
[[Category: Young, S.]]
[[Category: Autoimmunity]]
[[Category: Gpcr]]
[[Category: Graves' disease]]
[[Category: Receptor-autoantibody complex]]
[[Category: Signaling protein-immune system complex]]

Revision as of 16:35, 6 February 2013

File:2xwt.png

Template:STRUCTURE 2xwt

CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A BLOCKING TYPE TSHR AUTOANTIBODYCRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A BLOCKING TYPE TSHR AUTOANTIBODY

Template:ABSTRACT PUBMED 21247981

About this StructureAbout this Structure

2xwt is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1][xtra 2][xtra 3][xtra 4][xtra 5][xtra 6][xtra 7][xtra 8]

  1. ↑ Sanders P, Young S, Sanders J, Kabelis K, Baker S, Sullivan A, Evans M, Clark J, Wilmot J, Hu X, Roberts E, Powell M, Nunez Miguel R, Furmaniak J, Rees Smith B. Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody. J Mol Endocrinol. 2011 Feb 15;46(2):81-99. Print 2011. PMID:21247981 doi:10.1530/JME-10-0127
  2. ↑ Sanders J, Chirgadze DY, Sanders P, Baker S, Sullivan A, Bhardwaja A, Bolton J, Reeve M, Nakatake N, Evans M, Richards T, Powell M, Miguel RN, Blundell TL, Furmaniak J, Smith BR. Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody. Thyroid. 2007 May;17(5):395-410. PMID:17542669 doi:10.1089/thy.2007.0034
  3. ↑ Rees Smith B, Sanders J, Evans M, Tagami T, Furmaniak J. TSH receptor - autoantibody interactions. Horm Metab Res. 2009 Jun;41(6):448-55. PMID:19530271
  4. ↑ Sanders J, Jeffreys J, Depraetere H, Evans M, Richards T, Kiddie A, Brereton K, Premawardhana LD, Chirgadze DY, Nunez Miguel R, Blundell TL, Furmaniak J, Rees Smith B. Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function. Thyroid. 2004 Aug;14(8):560-70. PMID:15320966 doi:10.1089/1050725041692918
  5. ↑ Nunez Miguel R, Sanders J, Chirgadze DY, Furmaniak J, Rees Smith B. Thyroid stimulating autoantibody M22 mimics TSH binding to the TSH receptor leucine rich domain: a comparative structural study of protein-protein interactions. J Mol Endocrinol. 2009 May;42(5):381-95. Epub 2009 Feb 16. PMID:19221175 doi:10.1677/JME-08-0152
  6. ↑ Sanders J, Bolton J, Sanders P, Jeffreys J, Nakatake N, Richards T, Evans M, Kiddie A, Summerhayes S, Roberts E, Miguel RN, Furmaniak J, Smith BR. Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH. Thyroid. 2006 Dec;16(12):1195-206. PMID:17199429 doi:10.1089/thy.2006.16.1195
  7. ↑ Sanders J, Miguel RN, Bolton J, Bhardwaja A, Sanders P, Nakatake N, Evans M, Furmaniak J, Smith BR. Molecular interactions between the TSH receptor and a Thyroid-stimulating monoclonal autoantibody. Thyroid. 2007 Aug;17(8):699-706. PMID:17725428 doi:10.1089/thy.2007.0041
  8. ↑ Nunez Miguel R, Sanders J, Chirgadze DY, Blundell TL, Furmaniak J, Rees Smith B. FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity. J Mol Endocrinol. 2008 Sep;41(3):145-64. Epub 2008 Jul 7. PMID:18606720 doi:10.1677/JME-08-0040

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