Prp24

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.

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Prp24 (Pre-mRNA splicing Protein 24) is a Saccharomyces cerevisiae yeast protein that functions in the formation of base pair interactions between the U6 and U4 snRNPs (small nuclear ribonucleoproteins to form the U4/U6 di-snRNP in the assembly of the spliceosome. This protein is an octamer containing four RNA recognition motifs (RRMs) that function in the binding of Prp24 to U6 snRNA. These RRMs domains are conserved in structure and sequence in proteins orthologous to Prp24 in Homo sapiens and Schizosaccharomyces pombe, as well as in other proteins containing RRMs.

IntroductionIntroduction

Prp24 is a nuclear protein associated with the U6 snRNP and functions in the base pair annealing of U6 snRNA to U4 snRNA of the U4 snRNP.