3ofh: Difference between revisions
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{{STRUCTURE_3ofh| PDB=3ofh | SCENE= }} | {{STRUCTURE_3ofh| PDB=3ofh | SCENE= }} | ||
===Structured Domain of Mus musculus Mesd=== | ===Structured Domain of Mus musculus Mesd=== | ||
{{ABSTRACT_PUBMED_021397184}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MESD_MOUSE MESD_MOUSE]] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.<ref>PMID:12581525</ref> <ref>PMID:21397183</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3ofh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFH OCA]. | [[3ofh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OFH OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Collins, M N.]] | [[Category: Collins, M N.]] | ||
[[Category: Hendrickson, W A.]] | [[Category: Hendrickson, W A.]] | ||
[[Category: Chaperone]] | |||
[[Category: Lrp]] | |||
[[Category: Mesd]] | |||
[[Category: Molecular chaperone]] | |||
[[Category: Protein folding]] | |||
[[Category: Ywtd propeller]] | |||
Revision as of 11:24, 2 May 2013
Structured Domain of Mus musculus MesdStructured Domain of Mus musculus Mesd
Template:ABSTRACT PUBMED 021397184
FunctionFunction
[MESD_MOUSE] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.[1] [2]
About this StructureAbout this Structure
3ofh is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Hsieh JC, Lee L, Zhang L, Wefer S, Brown K, DeRossi C, Wines ME, Rosenquist T, Holdener BC. Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell. 2003 Feb 7;112(3):355-67. PMID:12581525
- ↑ Chen J, Liu CC, Li Q, Nowak C, Bu G, Wang J. Two Structural and Functional Domains of MESD Required for Proper Folding and Trafficking of LRP5/6. Structure. 2011 Mar 9;19(3):313-23. PMID:21397183 doi:10.1016/j.str.2011.01.010