Globular Proteins: Difference between revisions
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=== Intrinsically Unstructured Proteins === | === Intrinsically Unstructured Proteins === | ||
* <scene name='Globular_Proteins/Lef-1/1'>LEF-1</scene>, lymphoid enhancer-binding factor 1. LEF-1 is missing residues 26-47, and these residues are most likely missing because they form an unordered segment. Fill in this gap in your mind's eye, and you will see the large <scene name='Globular_Proteins/Lef-1_2/1'>surface area</scene> with which LEF-1 (yellow) binds to β-catenin. You may notice that residues 550-561 of β-catenin are missing, again an unordered segment. | * <scene name='Globular_Proteins/Lef-1/1'>LEF-1</scene>, lymphoid enhancer-binding factor 1. LEF-1 is missing residues 26-47, and these residues are most likely missing because they form an unordered segment. Fill in this gap in your mind's eye, and you will see the large <scene name='Globular_Proteins/Lef-1_2/1'>surface area</scene> with which LEF-1 (yellow) binds to β-catenin. You may notice that residues 550-561 of β-catenin are missing, again an unordered segment. | ||
* <scene name='Globular_Proteins/ | * <scene name='Globular_Proteins/Snap2/2'>SNAP-25</scene> - Domain N2 of synaptosomal-associated protein 25 from human bound to botulinum neurotoxin type A light chain (botox) from ''C. botulinum''. <scene name='Globular_Proteins/Snap/2'>Domain N2</scene> shown unbound but having the same conformation as the bound peptide. | ||
* <scene name='Globular_Proteins/Sara_sbd/2'>SARA SBD</scene> (SMAD anchor for receptor activation, SMAD-binding domain) - is the domain of the receptor that binds SMAD, and thereby activate the transforming growth factor-beta signaling pathway. Bound to <scene name='Globular_Proteins/Sara_sbd2/1'>SMAD2</scene> MH2 domain. | * <scene name='Globular_Proteins/Sara_sbd/2'>SARA SBD</scene> (SMAD anchor for receptor activation, SMAD-binding domain) - is the domain of the receptor that binds SMAD, and thereby activate the transforming growth factor-beta signaling pathway. Bound to <scene name='Globular_Proteins/Sara_sbd2/1'>SMAD2</scene> MH2 domain. | ||
* <scene name='Globular_Proteins/Hif-1alpha/1'>HIF- | * <scene name='Globular_Proteins/Hif-1alpha/1'>HIF-1alpha</scene> (Hypoxia-inducing factor 1α). Bound to <scene name='Globular_Proteins/Hif-1alpha2/1'>TAZ1</scene> (transcription activation zinc finger) | ||
* <scene name='Globular_Proteins/Hif-1b/1'>p160</scene> | * <scene name='Globular_Proteins/Hif-1b/1'>p160</scene> | ||
* <scene name='Globular_Proteins/P27-cdk2/1'>p27-Cdk2-Cyclin A</scene> - Cyclin-dependent kinase 2 bound to its activator cyclin A and both bound with a fragment (blue) of p27 which is a kinase inhibitor. Cyclin-dependent kinases have an important role in moving the call from one phase of the cell cycle to another. <scene name='Globular_Proteins/P27-cdk2-2/2'>p27</scene> shown by itself. | * <scene name='Globular_Proteins/P27-cdk2/1'>p27-Cdk2-Cyclin A</scene> - Cyclin-dependent kinase 2 bound to its activator cyclin A and both bound with a fragment (blue) of p27 which is a kinase inhibitor. Cyclin-dependent kinases have an important role in moving the call from one phase of the cell cycle to another. <scene name='Globular_Proteins/P27-cdk2-2/2'>p27</scene> shown by itself. | ||