3kec: Difference between revisions

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[[Image:3kec.png|left|200px]]
[[Image:3kec.png|left|200px]]


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{{STRUCTURE_3kec|  PDB=3kec  |  SCENE=  }}  
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===Crystal Structure of Human MMP-13 complexed with a phenyl-2H-tetrazole compound===
===Crystal Structure of Human MMP-13 complexed with a phenyl-2H-tetrazole compound===


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{{ABSTRACT_PUBMED_20005097}}
{{ABSTRACT_PUBMED_20005097}}


==About this Structure==
==About this Structure==
[[3kec]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEC OCA].  
[[3kec]] is a 2 chain structure of [[Matrix metalloproteinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEC OCA].  
 
==See Also==
*[[Matrix metalloproteinase|Matrix metalloproteinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:20005097</ref><references group="xtra"/>
<ref group="xtra">PMID:020005097</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Collins, B.]]
[[Category: Collins, B.]]
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[[Category: Schnute, M E.]]
[[Category: Schnute, M E.]]
[[Category: Shieh, H S.]]
[[Category: Shieh, H S.]]
[[Category: Collagen degradation]]
[[Category: Disease mutation]]
[[Category: Disulfide bond]]
[[Category: Extracellular matrix]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Metal-binding]]
[[Category: Metalloprotease]]
[[Category: No contact to zn]]
[[Category: Protease]]
[[Category: S1' inhibitor]]
[[Category: S1' specificity pocket]]
[[Category: Secreted]]
[[Category: Selective mmp-13 inhibitor]]
[[Category: Zymogen]]

Revision as of 04:36, 27 July 2012

File:3kec.png

Template:STRUCTURE 3kec

Crystal Structure of Human MMP-13 complexed with a phenyl-2H-tetrazole compoundCrystal Structure of Human MMP-13 complexed with a phenyl-2H-tetrazole compound

Template:ABSTRACT PUBMED 20005097

About this StructureAbout this Structure

3kec is a 2 chain structure of Matrix metalloproteinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. ↑ Schnute ME, O'Brien PM, Nahra J, Morris M, Howard Roark W, Hanau CE, Ruminski PG, Scholten JA, Fletcher TR, Hamper BC, Carroll JN, Patt WC, Shieh HS, Collins B, Pavlovsky AG, Palmquist KE, Aston KW, Hitchcock J, Rogers MD, McDonald J, Johnson AR, Munie GE, Wittwer AJ, Man CF, Settle SL, Nemirovskiy O, Vickery LE, Agawal A, Dyer RD, Sunyer T. Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorg Med Chem Lett. 2010 Jan 15;20(2):576-80. Epub 2009 Nov 22. PMID:20005097 doi:10.1016/j.bmcl.2009.11.081

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