3kf9: Difference between revisions
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{{STRUCTURE_3kf9| PDB=3kf9 | SCENE= }} | {{STRUCTURE_3kf9| PDB=3kf9 | SCENE= }} | ||
===Crystal structure of the SdCen/skMLCK complex=== | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/MYLK2_HUMAN MYLK2_HUMAN]] Familial isolated hypertrophic cardiomyopathy. Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:[http://omim.org/entry/192600 192600]]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:11733062</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CATR_SCHDU CATR_SCHDU]] This calcium-binding protein is found in the basal body complexes (the functional homolog of the centrosome in animal cell). In mitotic cells it is specifically associated with the poles of the mitotic spindles at the sites of the duplicated basal body complexes. [[http://www.uniprot.org/uniprot/MYLK2_HUMAN MYLK2_HUMAN]] Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.<ref>PMID:11733062</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3kf9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Scherffelia_dubia Scherffelia dubia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KF9 OCA]. | [[3kf9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Scherffelia_dubia Scherffelia dubia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KF9 OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Scherffelia dubia]] | [[Category: Scherffelia dubia]] | ||
[[Category: Assairi, L.]] | [[Category: Assairi, L.]] | ||
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[[Category: Miron, S.]] | [[Category: Miron, S.]] | ||
[[Category: Radu, L.]] | [[Category: Radu, L.]] | ||
[[Category: Calmodulin-binding]] | |||
[[Category: Cell cycle]] | |||
[[Category: Cell cycle-calcium-binding protein complex]] | |||
[[Category: Cell division]] | |||
[[Category: Centrin]] | |||
[[Category: Mitosis]] | |||
[[Category: Myosin light chain kinase]] | |||
Revision as of 05:48, 4 April 2013
Crystal structure of the SdCen/skMLCK complexCrystal structure of the SdCen/skMLCK complex
DiseaseDisease
[MYLK2_HUMAN] Familial isolated hypertrophic cardiomyopathy. Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.[1]
FunctionFunction
[CATR_SCHDU] This calcium-binding protein is found in the basal body complexes (the functional homolog of the centrosome in animal cell). In mitotic cells it is specifically associated with the poles of the mitotic spindles at the sites of the duplicated basal body complexes. [MYLK2_HUMAN] Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.[2]
About this StructureAbout this Structure
3kf9 is a 4 chain structure with sequence from Scherffelia dubia. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Davis JS, Hassanzadeh S, Winitsky S, Lin H, Satorius C, Vemuri R, Aletras AH, Wen H, Epstein ND. The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation. Cell. 2001 Nov 30;107(5):631-41. PMID:11733062
- ↑ Davis JS, Hassanzadeh S, Winitsky S, Lin H, Satorius C, Vemuri R, Aletras AH, Wen H, Epstein ND. The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation. Cell. 2001 Nov 30;107(5):631-41. PMID:11733062