Colicin E9: Difference between revisions
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<ref> PMID: 12804762 </ref> | <ref> PMID: 12804762 </ref> | ||
The endonuclease activity of colicin E9 forms channels in planar lipid bilayers. The E9 DNase mediates its own translocation across the cytoplasmic membrane, and the formation of ion channels is essential to this process. The association of colicin E9 with negative phospholipids results in a destabilisation of the DNase. This is protected by the colE9 immunity protein, [[Im9]], but not by the binding of zinc to the active site. Formation of this destabilising complex preempts channel formation by the DNase, and makes up the first step in the translocation of colE9 across the ''E. coli'' inner membrane. | |||
<ref> PMID: 15044477 <ref/> | |||
==Killing Activities== | ==Killing Activities== | ||
The cytotoxic activity of colE9 is DNase activity. <ref> PMID: 12804762 </ref> | The cytotoxic activity of colE9 is DNase activity. <ref> PMID: 12804762 </ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||