Interleukin-10: Difference between revisions
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RA is an autoimmune disorder that affects the [http://en.wikipedia.org/wiki/Synovial_membrane synovial] tissues via chronic synovitis. Chronic synovitis often results in joint destruction due to re-absorption of bone and the distruction of cartilage<ref name="ref5"> PMID:19758192</ref> <ref name="ref4"/>. | RA is an autoimmune disorder that affects the [http://en.wikipedia.org/wiki/Synovial_membrane synovial] tissues via chronic synovitis. Chronic synovitis often results in joint destruction due to re-absorption of bone and the distruction of cartilage<ref name="ref5"> PMID:19758192</ref> <ref name="ref4"/>. | ||
IL-10 is found to be spontaneously produce in synovial tissue of patients with RA and OA but not in normal synovial tissue. The variation in secretion of IL-10 is thought to be 75% under the control of the genetics of the individual<ref name="ref5"/>. When IL-10 is present there is an inhibition of the proinflammatory cytokines, namely TFN-α, IL-1α, IL-1β, IL-6, IL-8 <ref>PMID:1940799</ref>. | IL-10 is found to be spontaneously produce in synovial tissue of patients with RA and OA but not in normal synovial tissue. The variation in secretion of IL-10 is thought to be 75% under the control of the genetics of the individual<ref name="ref5"/>. When IL-10 is present there is an inhibition of the proinflammatory cytokines, namely TFN-α, IL-1α, IL-1β, IL-6, IL-8 <ref>PMID:1940799</ref>. | ||