3p8e: Difference between revisions
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{{STRUCTURE_3p8e| PDB=3p8e | SCENE= }} | {{STRUCTURE_3p8e| PDB=3p8e | SCENE= }} | ||
===Crystal structure of human DIMETHYLARGININE DIMETHYLAMINOHYDROLASE-1 (DDAH-1) covalently bound with N5-(1-iminopentyl)-L-ornithine=== | ===Crystal structure of human DIMETHYLARGININE DIMETHYLAMINOHYDROLASE-1 (DDAH-1) covalently bound with N5-(1-iminopentyl)-L-ornithine=== | ||
{{ABSTRACT_PUBMED_20979083}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DDAH1_HUMAN DDAH1_HUMAN]] Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020979083</ref><references group="xtra"/><references/> | ||
[[Category: Dimethylargininase]] | [[Category: Dimethylargininase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Robertus, J D.]] | [[Category: Robertus, J D.]] | ||
[[Category: Wang, Y.]] | [[Category: Wang, Y.]] | ||
[[Category: Ddah]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Nitric oxide synthase regulation]] | |||
Revision as of 11:31, 2 May 2013
Crystal structure of human DIMETHYLARGININE DIMETHYLAMINOHYDROLASE-1 (DDAH-1) covalently bound with N5-(1-iminopentyl)-L-ornithineCrystal structure of human DIMETHYLARGININE DIMETHYLAMINOHYDROLASE-1 (DDAH-1) covalently bound with N5-(1-iminopentyl)-L-ornithine
Template:ABSTRACT PUBMED 20979083
FunctionFunction
[DDAH1_HUMAN] Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
About this StructureAbout this Structure
3p8e is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Lluis M, Wang Y, Monzingo AF, Fast W, Robertus JD. Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1. ChemMedChem. 2010 Oct 26. PMID:20979083 doi:10.1002/cmdc.201000392