1uuv: Difference between revisions
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Revision as of 17:07, 30 October 2007
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NAPHTHALENE 1,2-DIOXYGENASE WITH NITRIC OXIDE AND INDOLE BOUND IN THE ACTIVE SITE.
OverviewOverview
Nitric oxide (NO) is commonly used as an analogue for dioxygen in, structural and spectroscopic studies of oxygen binding and oxygen, activation. In this study, crystallographic structures of naphthalene, dioxygenase (NDO) in complex with nitric oxide are reported. In the, presence of the aromatic substrate indole, NO is bound end-on to the, active-site mononuclear iron of NDO. The structural observations correlate, well with spectroscopic measurements of NO binding to NDO in solution., However, the end-on binding of NO is in contrast to the recently reported, structure of oxygen to the active-site iron of NDO that binds side-on., While NO is a good oxygen analogue with many similarities to O(2), the, different binding mode of NO to the active-site iron atom leads to, different ... [(full description)]
About this StructureAbout this Structure
1UUV is a [Protein complex] structure of sequences from [Pseudomonas putida] with FE, SO4, FES, EDO, IND and NO as [ligands]. Active as [Naphthalene 1,2-dioxygenase], with EC number [1.14.12.12]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
NO binding to naphthalene dioxygenase., Karlsson A, Parales JV, Parales RE, Gibson DT, Eklund H, Ramaswamy S, J Biol Inorg Chem. 2005 Aug;10(5):483-9. Epub 2005 Sep 23. PMID:15942729
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