2buc: Difference between revisions

Revision as of 17:43, 30 October 2007

CRYSTAL STRUCTURE OF PORCINE DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH A TETRAHYDROISOQUINOLINE INHIBITOR

OverviewOverview

The co-crystal structure of beta-phenethylamine fragment inhibitor 5 bound, to DPP-IV revealed that the phenyl ring occupied the proline pocket of the, enzyme. This finding provided the basis for a general hypothesis of a, reverse binding mode for beta-phenethylamine-based DPP-IV inhibitors., Novel inhibitor design concepts that obviate substrate-like, structure-activity relationships (SAR) were thereby enabled, and novel, potent inhibitors were discovered.

About this StructureAbout this Structure

2BUC is a [Single protein] structure of sequence from [Sus scrofa] with NAG, NDG, SO4 and 008 as [ligands]. Active as [Dipeptidyl-peptidase IV], with EC number [3.4.14.5]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

ReferenceReference

The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors., Nordhoff S, Cerezo-Galvez S, Feurer A, Hill O, Matassa VG, Metz G, Rummey C, Thiemann M, Edwards PJ, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1744-8. Epub 2006 Jan 11. PMID:16376544

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OCA

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