2zda: Difference between revisions
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[[Image:2zda.png|left|200px]] | [[Image:2zda.png|left|200px]] | ||
{{STRUCTURE_2zda| PDB=2zda | SCENE= }} | {{STRUCTURE_2zda| PDB=2zda | SCENE= }} | ||
===Exploring Thrombin S1 pocket=== | ===Exploring Thrombin S1 pocket=== | ||
{{ABSTRACT_PUBMED_19520086}} | {{ABSTRACT_PUBMED_19520086}} | ||
==About this Structure== | ==About this Structure== | ||
[[2zda]] is a 3 chain structure of [[Hirudin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZDA OCA]. | [[2zda]] is a 3 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZDA OCA]. | ||
==See Also== | ==See Also== | ||
*[[Hirudin]] | *[[Hirudin|Hirudin]] | ||
*[[Thrombin|Thrombin]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:019520086</ref><ref group="xtra">PMID:019409395</ref><references group="xtra"/> | ||
[[Category: Hirudo medicinalis]] | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
| Line 32: | Line 23: | ||
[[Category: Klebe, G.]] | [[Category: Klebe, G.]] | ||
[[Category: Acute phase]] | [[Category: Acute phase]] | ||
[[Category: Blood clotting-hydrolase inhibitor complex]] | |||
[[Category: Blood clotting/hydrolase inhibitor]] | [[Category: Blood clotting/hydrolase inhibitor]] | ||
[[Category: Blood coagulation]] | [[Category: Blood coagulation]] | ||
[[Category: Cleavage on pair of basic residue]] | [[Category: Cleavage on pair of basic residue]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
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[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
[[Category: Kringle]] | [[Category: Kringle]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
Revision as of 12:20, 26 July 2012
Exploring Thrombin S1 pocketExploring Thrombin S1 pocket
Template:ABSTRACT PUBMED 19520086
About this StructureAbout this Structure
2zda is a 3 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Baum B, Muley L, Heine A, Smolinski M, Hangauer D, Klebe G. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin. J Mol Biol. 2009 Aug 21;391(3):552-64. Epub 2009 Jun 9. PMID:19520086 doi:10.1016/j.jmb.2009.06.016
- ↑ Baum B, Mohamed M, Zayed M, Gerlach C, Heine A, Hangauer D, Klebe G. More than a simple lipophilic contact: a detailed thermodynamic analysis of nonbasic residues in the s1 pocket of thrombin. J Mol Biol. 2009 Jul 3;390(1):56-69. Epub 2009 May 3. PMID:19409395 doi:10.1016/j.jmb.2009.04.051
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Pages with broken file links
- Hirudo medicinalis
- Homo sapiens
- Thrombin
- Baum, B.
- Heine, A.
- Klebe, G.
- Acute phase
- Blood clotting-hydrolase inhibitor complex
- Blood clotting/hydrolase inhibitor
- Blood coagulation
- Cleavage on pair of basic residue
- Disease mutation
- Gamma-carboxyglutamic acid
- Glycoprotein
- Kringle
- Protease
- Secreted
- Serine protease
- Zymogen