1vyd: Difference between revisions
New page: left|200px<br /> <applet load="1vyd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vyd, resolution 2.30Å" /> '''CRYSTAL STRUCTURE O... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
1VYD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]] with HEM as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VYD OCA]]. | 1VYD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]] with HEM as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VYD OCA]]. | ||
==Reference== | ==Reference== | ||
| Line 27: | Line 27: | ||
[[Category: redox]] | [[Category: redox]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:22:52 2007'' | ||
Revision as of 09:18, 30 October 2007
|
CRYSTAL STRUCTURE OF CYTOCHROME C2 MUTANT G95E
OverviewOverview
All class I c-type cytochromes studied to date undergo a dynamic process, in the oxidized state, which results in the transient breaking of the, iron-methionine-sulfur bond and sufficient movement to allow the binding, of exogenous ligands (imidazole in this work). In the case of Rhodobacter, capsulatus cytochrome c(2), the sixth heme ligand Met96 and up to 14, flanking residues (positions 88-100, termed the hinge region), located, between two relatively rigid helical regions, may be involved in, structural changes leading to a transient high-spin species able to bind, ligands. We have examined 14 mutations at 9 positions in the hinge region, of Rhodobacter capsulatus cytochrome c(2) and have determined the, structure of the G95E mutant. Mutations near the N- and C-terminus of the, hinge ... [(full description)]
About this StructureAbout this Structure
1VYD is a [Single protein] structure of sequence from [Rhodobacter capsulatus] with HEM as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Protein dynamics in the region of the sixth ligand methionine revealed by studies of imidazole binding to Rhodobacter capsulatus cytochrome c2 hinge mutants., Dumortier C, Fitch J, Van Petegem F, Vermeulen W, Meyer TE, Van Beeumen JJ, Cusanovich MA, Biochemistry. 2004 Jun 22;43(24):7717-24. PMID:15196014
Page seeded by OCA on Tue Oct 30 08:22:52 2007