Fibronectin: Difference between revisions
New page: left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]] {{STRUCTURE_1fbr| PDB=1fbr | SIZE=300| SCENE= |right|CAPTION=Fibronectin 4-5FnI fragment [[1... |
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[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]] | [[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]] | ||
{{STRUCTURE_1fbr| PDB=1fbr | SIZE=300| SCENE= |right|CAPTION=Fibronectin 4-5FnI fragment [[1fbr]] }} | {{STRUCTURE_1fbr| PDB=1fbr | SIZE=300| SCENE=Fibronectin/Cv/1 |right|CAPTION=Fibronectin 4-5FnI fragment [[1fbr]] }} | ||
[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]). | [[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]). | ||
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=== Fn module FnI === | === Fn module FnI === | ||
[[3m7p]] – hFn GBD – human | [[3m7p]] – hFn GBD – human<br /> | ||
1e8b, 1e88, 1qo6 - hFn GBD – NMR | [[1e8b]], [[1e88]], [[1qo6]] - hFn GBD – NMR<br /> | ||
3gxe, 3ejh – hFn 8-9FnI+collagen alpha-1 | [[3gxe]], [[3ejh]] – hFn 8-9FnI+collagen alpha-1<br /> | ||
1fbr - hFn 4-5FnI | [[1fbr]] - hFn 4-5FnI<br /> | ||
2rky, 2rl0 – hFn 4-5FnI+Fn binding peptide | [[2rky]], [[2rl0]] – hFn 4-5FnI+Fn binding peptide<br /> | ||
2rkz, 3cal - hFn 2-3FnI+Fn binding peptide | [[2rkz]], [[3cal]] - hFn 2-3FnI+Fn binding peptide<br /> | ||
2cg6, 2cg7 - hFn 2-3FnI | [[2cg6]], [[2cg7]] - hFn 2-3FnI<br /> | ||
2cku - hFn 2-3FnI – NMR | [[2cku]] - hFn 2-3FnI – NMR<br /> | ||
1o9a - hFn 1-2FnI+B3 from FNBB – NMR | [[1o9a]] - hFn 1-2FnI+B3 from FNBB – NMR<br /> | ||
2ec3 – hFn 11FnI – NMR | [[2ec3]] – hFn 11FnI – NMR<br /> | ||
1qgb – hFn FnI N-terminal - NMR | [[1qgb]] – hFn FnI N-terminal - NMR<br /> | ||
2ck2 – hFn (mutant) core swapped | [[2ck2]] – hFn (mutant) core swapped<br /> | ||
1j8k – hFn extra domain 2 – NMR | [[1j8k]] – hFn extra domain 2 – NMR<br /> | ||
1fnh – hFn heparin and integrin binding domains | [[1fnh]] – hFn heparin and integrin binding domains | ||
=== Fn module FnII === | === Fn module FnII === | ||
2fn2 – hFn 2FnII – NMR | [[2fn2]] – hFn 2FnII – NMR | ||
=== Fn module FnIII === | === Fn module FnIII === | ||
2h41, 2h45 – hFn 2FnIII – NMR | [[2h41]], [[2h45]] – hFn 2FnIII – NMR<br /> | ||
1oww - hFn 1FnIII – NMR | [[1oww]] - hFn 1FnIII – NMR<br /> | ||
2ha1 - hFn 1-2FnIII – NMR | [[2ha1]] - hFn 1-2FnIII – NMR<br /> | ||
2crm - hFn 4FnIII – NMR | [[2crm]] - hFn 4FnIII – NMR<br /> | ||
2crz - hFn 5FnIII – NMR | [[2crz]] - hFn 5FnIII – NMR<br /> | ||
1fna, 1ttf, 1ttg – hFn 10FnIII | [[1fna]], [[1ttf]], [[1ttg]] – hFn 10FnIII<br /> | ||
1fnf – hFn 7-10FnIII | [[1fnf]] – hFn 7-10FnIII<br /> | ||
2fnb – hFn FnIII ed-b domain – NMR | [[2fnb]] – hFn FnIII ed-b domain – NMR<br /> | ||
1mfn, 2mfn – Fn 9-10FnIII – mouse - NMR | [[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR | ||
