Ofatumumab: Difference between revisions
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===Mechanism of Action=== | ===Mechanism of Action=== | ||
B-Lymphocyte Antigen CD20 is a phosphoprotein expressed on the surface of all mature B-cells. B-cells play a key role in the humoral immune system by acting as antigen-presenting cells (which activate T-cells) and by eventually producing antibodies to against invading antigens.<ref>doi:10.1016/j.it.2006.07.005</ref> | |||
The CD20 molecule is highly expressed in both normal and malignant B cells and, when bound by an antibody, sends a signal across the membrane to control growth and trigger death of certain tumor cells. | The CD20 molecule is highly expressed in both normal and malignant B cells and, when bound by an antibody, sends a signal across the membrane to control growth and trigger death of certain tumor cells. | ||