Molecular Playground/Taxol: Difference between revisions
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Originally, paclitaxel was produced through the extraction of the drug from the bark of ''Taxus'' trees. This process was unsustainable because nearly 40,000 trees were required to meet the demands for the drug each year. A semi-synthetic route was developed and utilized for paclitaxel production which utilized Taxol precursors which can be extracted from the needles of ''Taxus'' trees. This process was more sustainable because the ''Taxus'' needles could be harvested depending on their seasonal availability. Currently, paclitaxel is being produced through plant cell culture. This was the first plant cell culture production route approved by the FDA for the production of a pharmaceutical. | Originally, paclitaxel was produced through the extraction of the drug from the bark of ''Taxus'' trees. This process was unsustainable because nearly 40,000 trees were required to meet the demands for the drug each year. A semi-synthetic route was developed and utilized for paclitaxel production which utilized Taxol precursors which can be extracted from the needles of ''Taxus'' trees. This process was more sustainable because the ''Taxus'' needles could be harvested depending on their seasonal availability. Currently, paclitaxel is being produced through plant cell culture. This was the first plant cell culture production route approved by the FDA for the production of a pharmaceutical. | ||
Docetaxel (Taxotere, sanofi-aventis) is a semi-synthetic analog of Taxol that was discovered during the search for a more easily produced taxane anti-cancer agent. The hydroxyl group modification on docetaxel leads to an increase in the lipid solubility of the drug. It was first approved by the FDA in 1996 and is currently used in the treatment of breast, stomach and prostate cancer. | Docetaxel (Taxotere, sanofi-aventis) is a semi-synthetic analog of Taxol that was discovered during the search for a more easily produced taxane anti-cancer agent. The hydroxyl group modification on docetaxel leads to an increase in the lipid solubility of the drug. It was first approved by the FDA in 1996 and is currently used in the treatment of breast, stomach and prostate cancer. Currently, Taxotere is produced from paclitaxel precursors which are extracted from ''Taxus brevifolia'', the readily available Wester Yew. | ||
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caption='Paclitaxel (also known as Taxol)' /> <scene name='Rohan_Patil/Sandbox1/Taxol/6'>Paclitaxel</scene> | caption='Paclitaxel (also known as Taxol)' /> <scene name='Rohan_Patil/Sandbox1/Taxol/6'>Paclitaxel</scene> | ||
Molecular Playground Banner: "Paclitaxel (Taxol),a plant-derived natural product to treat cancer" | |||
<applet size='[450,338]' frame='true' align='right' | <applet size='[450,338]' frame='true' align='right' | ||
caption='Docetaxel(also known as Taxotere)' /> <scene name='Molecular_Playground/Taxol/Docetaxel/4'>Docetaxel</scene> | caption='Docetaxel(also known as Taxotere)' /> <scene name='Molecular_Playground/Taxol/Docetaxel/4'>Docetaxel</scene> | ||