Donepezil: Difference between revisions
David Canner (talk | contribs) No edit summary |
David Canner (talk | contribs) No edit summary |
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! [[Rivastigmine]] | ! [[Rivastigmine]] | ||
! [[Galantamine]] | ! [[Galantamine]] | ||
! [[Metrifonate]] | |||
|- | |- | ||
! [[Pharmaceutical_Drugs#Tmax|T<sub>max</sub>]] (hr) | ! [[Pharmaceutical_Drugs#Tmax|T<sub>max</sub>]] (hr) | ||
! 3.6 | ! 3.6 | ||
! | ! 1-2 | ||
! | ! .3 | ||
! | ! .5 | ||
! .5 | |||
|- | |- | ||
! [[Pharmaceutical_Drugs#Cmax|C<sub>max</sub>]] (ng/ml) | ! [[Pharmaceutical_Drugs#Cmax|C<sub>max</sub>]] (ng/ml) | ||
! 6.5 | ! 6.5 | ||
! | ! -- | ||
! | ! -- | ||
! | ! 500 | ||
! 543 | |||
|- | |- | ||
! [[Pharmaceutical_Drugs#Bioavailability_.28F.29|Bioavailability]] (%) | ! [[Pharmaceutical_Drugs#Bioavailability_.28F.29|Bioavailability]] (%) | ||
! 100 | ! 100 | ||
! | ! [[Tacrine]] | ||
! | ! [[Rivastigmine]] | ||
! | ! [[Galantamine]] | ||
! [[Metrifonate]] | |||
|- | |- | ||
! [[Pharmaceutical_Drugs#Protein_Binding|Protein Binding]] (%) | ! [[Pharmaceutical_Drugs#Protein_Binding|Protein Binding]] (%) | ||
! 96 | ! 96 | ||
! | ! [[Tacrine]] | ||
! | ! [[Rivastigmine]] | ||
! | ! [[Galantamine]] | ||
! [[Metrifonate]] | |||
|- | |- | ||
! [[Pharmaceutical_Drugs#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr) | ! [[Pharmaceutical_Drugs#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr) | ||
! 70 | ! 70 | ||
! | ! [[Tacrine]] | ||
! | ! [[Rivastigmine]] | ||
! | ! [[Galantamine]] | ||
! [[Metrifonate]] | |||
|- | |- | ||
! [[Pharmaceutical_Drugs#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr) | ! [[Pharmaceutical_Drugs#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr) | ||
! 380 | ! 380 | ||
! | ! [[Tacrine]] | ||
! | ! [[Rivastigmine]] | ||
! | ! [[Galantamine]] | ||
! [[Metrifonate]] | |||
|- | |- | ||
! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM) | ! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM) | ||
! 53.6 | ! 53.6 | ||
! | ! 93 | ||
! | ! 181390 | ||
! | ! 1995 | ||
|- | |- | ||
! Dosage (mg) | ! Dosage (mg) | ||
! 5 | ! 5 | ||
! | ! [[Tacrine]] | ||
! | ! [[Rivastigmine]] | ||
! | ! [[Galantamine]] | ||
! [[Metrifonate]] | |||
|- | |- | ||
! Metabolism | ! Metabolism | ||
! Hepatic (CYP2D6 & CYP3A4) | ! Hepatic (CYP2D6 & CYP3A4) | ||
! | ! [[Tacrine]] | ||
! | ! [[Rivastigmine]] | ||
! | ! [[Galantamine]] | ||
! [[Metrifonate]] | |||
|} | |} | ||