User:David Canner/Sandbox good: Difference between revisions

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<center><scene name='User:David_Canner/Sandbox_P/Nsh2__and_helical_ligand_out/1'>Initial Scene (Reset)</scene></center>

This loop in <scene name='User:David_Canner/Sandbox_P/Nsh2__and_helical_ligand_out/2'>the helical domain </scene> which contains the hotspots (residues 542-546) is located precisely where <scene name='User:David_Canner/Sandbox_P/Nsh2_ligand_just_ligand_full/1'> the phosphopeptide of NSH2 ligands, like PDGFR, bind to NSH2.</scene> The salt bridge formed between <scene name='User:David_Canner/Sandbox_P/Nsh2_disruption_of_salt/1'>Glu 542 and nSH2 is disrupted upon binding phosphorylated peptides</scene> like PDGFR, eliminating nSH2-mediated inhibition of p110α and activating the enzyme to phosphorylate PIP2 into PIP3.

====Tip #4: When ~~Transitioning~~ focus to a new domain, it is best to zoom out and orient the reader to the new domain of interest====

====Tip #4: When switching focus to a new domain, it is best to zoom out and orient the reader to the new domain of interest====

=====Example from the page [[The Structure of PI3K]]:=====

<center><scene name='User:David_Canner/Sandbox_P/Full/4'>Initial Scene (Reset)</scene> </center>

@@ Line 21: / Line 21: @@
 <center><scene name='User:David_Canner/Sandbox_P/Nsh2__and_helical_ligand_out/1'>Initial Scene (Reset)</scene></center>
 This loop in <scene name='User:David_Canner/Sandbox_P/Nsh2__and_helical_ligand_out/2'>the helical domain </scene> which contains the hotspots (residues 542-546) is located precisely where <scene name='User:David_Canner/Sandbox_P/Nsh2_ligand_just_ligand_full/1'> the phosphopeptide of NSH2 ligands, like PDGFR, bind to NSH2.</scene> The salt bridge formed between <scene name='User:David_Canner/Sandbox_P/Nsh2_disruption_of_salt/1'>Glu 542 and nSH2 is disrupted upon binding phosphorylated peptides</scene> like PDGFR, eliminating nSH2-mediated inhibition of p110α and activating the enzyme to phosphorylate PIP2 into PIP3.
-====Tip #4: When Transitioning focus to a new domain, it is best to zoom out and orient the reader to the new domain of interest====
+====Tip #4: When switching focus to a new domain, it is best to zoom out and orient the reader to the new domain of interest====
 =====Example from the page [[The Structure of PI3K]]:=====
 <center><scene name='User:David_Canner/Sandbox_P/Full/4'>Initial Scene (Reset)</scene> </center>