AZT-resistant HIV-1 reverse transcriptase: Difference between revisions
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[[Image:RT finger.png]]'''Fingers Subdomain''' [[Image:RT palm.png]]''' Palm Subdomain''' | [[Image:RT finger.png]]'''Fingers Subdomain''' [[Image:RT palm.png]]''' Palm Subdomain''' | ||
[[Image:RT thumb.png]] '''Thumb Subdomain''' | |||
The nucleic-acid binding cleft is primarily formed by the p66 polymerase and RNase H subdomains. The p51 thumb and connection subdomains form the floor of the binding cleft. In this way, the binding cleft is positioned so that both the polymerase and the RNAse H active sites come in contact with the nucleic acid. | The nucleic-acid binding cleft is primarily formed by the p66 polymerase and RNase H subdomains. The p51 thumb and connection subdomains form the floor of the binding cleft. In this way, the binding cleft is positioned so that both the polymerase and the RNAse H active sites come in contact with the nucleic acid. | ||