AZT-resistant HIV-1 reverse transcriptase: Difference between revisions
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2. excision- removal of AZTTP from the viral DNA after it has been incorporated into the host genome | 2. excision- removal of AZTTP from the viral DNA after it has been incorporated into the host genome | ||
The excision mechanism has been shown to result from a set of mutations. [[Reverse transcriptase]] isolated from patients with AZT-resistant viruses do not typically have all of these mutations, however, combinations of the mutations give rise to high levels of resistance to AZT. | The excision mechanism has been shown to result from a set of mutations. [[Reverse transcriptase]] isolated from patients with AZT-resistant viruses do not typically have all of these mutations, however, combinations of the mutations give rise to high levels of resistance to AZT. AZT-resistant [[reverse transcriptase]] incorporates AZTTP just as efficiently as the wild-type, yet it has an improved ability to removed incorporated AZT from the 5'end of the template strand. | ||
==References== | ==References== | ||