AZT-resistant HIV-1 reverse transcriptase: Difference between revisions

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==Structure of Reverse Transcriptase==
==Structure of Reverse Transcriptase==
[[Reverse transcriptase]] is a heterodimer of two related <scene name='AZT-resistant_HIV-1_reverse_transcriptase/Subunits/1'>subunits</scene>: p66 and p51.  These subunits consist of four sub-domains fingers, thumb, palm, and connection, although the positions of the sub-domains relative to each other is different for each subunit.
{{STRUCTURE_3klg |  PDB=3klg  |  SCENE=  }}
{{STRUCTURE_3klg |  PDB=3klg  |  SCENE=  }}
[[Reverse transcriptase]] is a heterodimer of two related <scene name='AZT-resistant_HIV-1_reverse_transcriptase/Subunits/1'>subunits</scene>: p66 and p51.  These subunits consist of four sub-domains fingers, thumb, palm, and connection, although the positions of the sub-domains relative to each other is different for each subunit.


==Inhibition of Reverse Transcriptase Activity==
==Inhibition of Reverse Transcriptase Activity==

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Alexandra Clement, Michal Harel, Alexander Berchansky, David Canner