Simvastatin: Difference between revisions
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The Statins are one of the safest drug classes to reach block buster status. Typical adverse events include muscle weakness, headache dizziness and slightly increased creatinine kinase (CK) levels (an indication of kidney and smooth muscle damage), although these are common to all the statins (with the exception of elevated CK levels which only occurs in [[Atorvastatin]], [[Rosuvastatin]], and Simvastatin)<ref>PMID:20456733</ref> In March, 2010, the FDA issued a warning about an increased rate of Rhabdomyolysis, a dangerous breakdown of muscle fiber, releasing [[myoglobin]] into the bloodstream, potentially resulting in severe kidney damage. Although these concerns are not enough to have patients cease use of Zocor, it is important for the public to be aware of the issue. <ref>http://www.reuters.com/article/idUSTRE62I3YW20100319</ref> | The Statins are one of the safest drug classes to reach block buster status. Typical adverse events include muscle weakness, headache dizziness and slightly increased creatinine kinase (CK) levels (an indication of kidney and smooth muscle damage), although these are common to all the statins (with the exception of elevated CK levels which only occurs in [[Atorvastatin]], [[Rosuvastatin]], and Simvastatin)<ref>PMID:20456733</ref> In March, 2010, the FDA issued a warning about an increased rate of Rhabdomyolysis, a dangerous breakdown of muscle fiber, releasing [[myoglobin]] into the bloodstream, potentially resulting in severe kidney damage. Although these concerns are not enough to have patients cease use of Zocor, it is important for the public to be aware of the issue. <ref>http://www.reuters.com/article/idUSTRE62I3YW20100319</ref> | ||
===Interesting Facts=== | ===Interesting Facts=== | ||
* As with other statins which are metabolized by the CYP3A4 liver enzyme, the pharmacokinetics of Simvastatin are altered significantly by consumption of grapefruit juice. C<sub>max</sub> values of Simvastatin (40mg doses) increased by nearly 300%, t<sub>max</sub> increased 100%,, the half life decreased by 50%, and AUC increased by nearly 300%. These results are even more pronounced for active Simvastatin metabolites. <ref>DOI 10.1111/ | * As with other statins which are metabolized by the CYP3A4 liver enzyme, the pharmacokinetics of Simvastatin are altered significantly by consumption of grapefruit juice. C<sub>max</sub> values of Simvastatin (40mg doses) increased by nearly 300%, t<sub>max</sub> increased 100%,, the half life decreased by 50%, and AUC increased by nearly 300%. These results are even more pronounced for active Simvastatin metabolites. <ref>DOI: 10.1111/j.1365-2125.2004.02095.x</ref> | ||
===The Jist=== | ===The Jist=== | ||
===References=== | ===References=== | ||