DNA: Difference between revisions
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<applet load='B-DNA.pdb' size='330' frame='true' align='left' caption='B-DNA' scene ='DNA/Bdnasf/1' /> | <applet load='B-DNA.pdb' size='330' frame='true' align='left' caption='B-DNA' scene ='DNA/Bdnasf/1' /> | ||
In a DNA double helix the <scene name='User:Adithya_Sagar/Workbench_newDNA/B-dna/16'>beta-glycosyl bonds</scene> between C<sub>1'</sub>-N<sub>1</sub> branch off from one side of the base pair and do not lie opposite to each other. This results in unequally spaced sugar-phosphate backbones and gives rise to two grooves: the | In a DNA double helix the <scene name='User:Adithya_Sagar/Workbench_newDNA/B-dna/16'>beta-glycosyl bonds</scene> between C<sub>1'</sub>-N<sub>1</sub> branch off from one side of the base pair and do not lie opposite to each other. This results in unequally spaced sugar-phosphate backbones and gives rise to two grooves: the | ||
<scene name='DNA/B-dna/ | <scene name='DNA/B-dna/32'>major groove</scene> and the <scene name='User:Adithya_Sagar/Workbench_newDNA/B-dna/21'>minor groove</scene> of different width and depth. The minor groove is at the O<sub>2</sub> side of base pair and the major groove is on the opposite side.The floor of major groove is filled with nitrogen and oxygen atoms that project inward whereas in the minor groove they project outward. The larger size of major groove allows for the binding of DNA specific proteins.<ref name="Saenger"> Saenger, Wolfram (1984). ''Principles of Nucleic Acid Structure '' (1st ed). Springer-Verlag. pp. 398. ISBN 0-12-645750-6.</ref><ref name='Watson'> Watson, James D, Nancy H. Hopkins, Jeffrey W. Roberts, Joan Argetsinger Steitz, Alan M.Weiner ''Molecular Biology of Gene'' (4th ed.). The Benjamin/Cummings Publishing Company Inc.pp. 239-249. ISBN 0-8053-9612-8</ref> | ||