Neurexin: Difference between revisions
New page: left|200px|thumb|Crystal Structure of mouse β-neurexin 1 [[3bod]] {{STRUCTURE_3bod| PDB=3bod | SIZE=300| SCENE= |right|CAPTION=Mouse β-neurexin 1 3bod }} |
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[[Image:3bod.png|left|200px|thumb|Crystal Structure of mouse β-neurexin 1 [[3bod]]]] | [[Image:3bod.png|left|200px|thumb|Crystal Structure of mouse β-neurexin 1 [[3bod]]]] | ||
{{STRUCTURE_3bod| PDB=3bod | SIZE=300| SCENE= |right|CAPTION=Mouse β-neurexin 1 [[3bod]] }} | {{STRUCTURE_3bod| PDB=3bod | SIZE=300| SCENE=Neurexin/Cv/1 |right|CAPTION=Mouse β-neurexin 1 [[3bod]] }} | ||
[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The α-NRXN contains 6 homologous LNS domains while the β-NRXN contains only LNS6. The images at the left and at the right correspond to one representative NRXN, ''i.e.'' the crystal structure of mouse β-neurexin 1 ([[3bod]]). | |||
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== 3D Structures of Neurexin == | |||
=== α-NRXN === | |||
[[2h0b]] - bα-NRXN-1 LNS2 – bovine<br /> | |||
[[2r16]] - bα-NRXN-1 LNS 4<br /> | |||
=== β-NRXN === | |||
[[3mw2]] – mβ-NRXN-1 +splice insert 4 – mouse<br /> | |||
[[3bod]] - mβ-NRXN-1<br /> | |||
[[3bop]] - mβ-NRXN-2d4<br /> | |||
[[3mw3]], [[2r1b]] - rβ-NRXN-2 +splice insert 4 – rat<br /> | |||
[[2r1b]] - rβ-NRXN-1 +splice insert 4<br /> | |||
[[2r1d]] - rβ-NRXN-1 +Ca<br /> | |||
[[1c4r]] - rβ-NRXN-1<br /> | |||
[[3mw4]] - mβ-NRXN-3<br /> | |||
=== NRXN+NLGN === | |||
[[2xb6]], [[2wqz]] – rβ-NRXN-1 +hNLGN-4 cholinesterase domain<br /> | |||
[[3b3q]] - hNRXN-1 LNS domain+mNLGN-1 cholinesterase domain<br /> | |||
[[3biw]] - rβ-NRXN-1 +rNLGN-1 cholinesterase domain<br /> | |||
Revision as of 13:48, 27 October 2010
Neurexins (NRXN) are a family of presynaptic proteins which bind to the postsynaptic Neuroligin (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The α-NRXN contains 6 homologous LNS domains while the β-NRXN contains only LNS6. The images at the left and at the right correspond to one representative NRXN, i.e. the crystal structure of mouse β-neurexin 1 (3bod).
3D Structures of Neurexin3D Structures of Neurexin
α-NRXNα-NRXN
2h0b - bα-NRXN-1 LNS2 – bovine
2r16 - bα-NRXN-1 LNS 4
β-NRXNβ-NRXN
3mw2 – mβ-NRXN-1 +splice insert 4 – mouse
3bod - mβ-NRXN-1
3bop - mβ-NRXN-2d4
3mw3, 2r1b - rβ-NRXN-2 +splice insert 4 – rat
2r1b - rβ-NRXN-1 +splice insert 4
2r1d - rβ-NRXN-1 +Ca
1c4r - rβ-NRXN-1
3mw4 - mβ-NRXN-3
NRXN+NLGNNRXN+NLGN
2xb6, 2wqz – rβ-NRXN-1 +hNLGN-4 cholinesterase domain
3b3q - hNRXN-1 LNS domain+mNLGN-1 cholinesterase domain
3biw - rβ-NRXN-1 +rNLGN-1 cholinesterase domain