3ki7: Difference between revisions
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{{STRUCTURE_3ki7| PDB=3ki7 | SCENE= }} | {{STRUCTURE_3ki7| PDB=3ki7 | SCENE= }} | ||
===Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-I=== | ===Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-I=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q5EK40_VIBCH Q5EK40_VIBCH]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3ki7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI7 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Vibrio cholerae]] | [[Category: Vibrio cholerae]] | ||
[[Category: Edwards, P R.]] | [[Category: Edwards, P R.]] | ||
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[[Category: Toxin]] | [[Category: Toxin]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||