Pharmaceutical Drug Targets and Diseases: Difference between revisions

David Canner (talk | contribs)
No edit summary
David Canner (talk | contribs)
No edit summary
Line 41: Line 41:


**Cancer
**Cancer
***[[Antizyme Inhibitor]]
*** See: [[Cancer]]
***Caspases
****[[Molecular_Playground/Caspase-6|Caspase-6]]
****[[Molecular_Playground/Caspase-7_Dynamics|Caspase-7 Dynamics]]
****[[Molecular_Playground/Caspase-9_Regulation|Caspase-9 Regulation]]
***[[User:Greg_Black/Sandbox_1|Cisplatin Information]]
***[[Michael Purol Sandbox 1|Cyclin Dependent Kinase Inhibitor]]
***[[NADPH Cytochrome P450 Oxidoreductase|Cytochrome P450 Oxidoreductase]]
***[[6-deoxyerythronolide_B_synthase_%28DEBS%29|DEBS]]
***[[Dihydrofolate_reductase|Dihydrofolate Reductase, the Target of Methotrexate]]
***[[Farnesoid X Receptor]]
***Growth Factors & Receptors
****Epidermal Growth Factor
*****[[Epidermal Growth Factor]]
*****[[Epidermal Growth Factor Receptor]]
****[[Hepatocyte Growth Factor Receptor]]
****[[Human Epidermal Growth Factor Receptor 2]]
****Insulin-Like Growth Factor
*****[[Insulin-Like Growth Factor-1]]
*****[[Insulin-Like Growth Factor-1 Receptor]]
****Vascular Growth Factor
*****[[Vascular Endothelial Growth Factor]]
*****[[Vascular Endothelial Growth Factor Receptor]]
***[[Molecular_Playground/FIH|Hypoxia Inducible Factor (HIF)]]
***[[User:Yash_Patankar/Sandbox_1|Heat Shock Protein 90]]
***[[1ebm|Human 8-Oxoguanine Glycosylase Structure and Mechanism (HOGG1)]]
***Kinases
****[[Cory_Tiedeman_sandbox|Cyclin Dependent Kinase-4]]
****[[Cell Division Cycle 7-Related Protein Kinase]]
****[[Mammalian Target of Rapamycin]]
****Mitogen-Activated Proteins
*****Mitogen-Activated Protein Kinase
*****Mitogen-Activated Protein Kinase Kinase
*****Mitogen-Activated Protein Kinase Kinase Kinase
******[[c-Raf]]
****[[Phosphatidylinositol 3-Kinase]]
****[[SRC]]
***[[P-glycoprotein:_Why_Cancer_Drugs_Fail|P-Glycoprotein: Why Cancer Drugs Fail]]
***Oncogenes
****[[C-Myc]] - Proto-Oncogenic Gene
****[[P53]] - Tumor Suppressing Gene
****[[PTEN]]
****[[Matt Routh sandbox|MDM2 Bound to p53]]
****[[SRC]] - Proto-Oncogenic Tyrosine Kinase Gene
***[[Ann_Taylor_sandbox_Proteins_in_Cancer|Proteins in Cancer]]
***[[Ras|Ras Superfamily]]
***[[Chad Sorenson sandbox 1|Retinoblastoma Protein]]
***[[Molecular_Playground/Taxol|Taxol Information]]
***[[Telomerase Reverse Transcriptase]]
***[[User:Sarah Abdalla/Thioredoxin Reductase|Thioredoxin Reductase]]
***[[Molecular_Playground/TRAIL|Tumor-Necrosis Factor Apoptosis-Inducing Ligand]]
***[[Molecular_Playground/YKL-40|YKL-40]]


**Compromised Immune System
**Compromised Immune System
Line 102: Line 51:


**Diabetes & Hypoglycemia
**Diabetes & Hypoglycemia
***[[Molecular_Playground/Insulin|Insulin Information]]
*** [[See: Diabetes]]
***[[Sandbox 67|Insulin Structure]]
***[[User:Mary Ball/Leptin|Leptin]]
***[[Peroxisome Proliferator-Activated Receptors]]
***[[Molecular_Playground/YKL-40|YKL-40]]


**Digestive Diseases
**Digestive Diseases
Line 125: Line 70:


**Metabolic Disorders
**Metabolic Disorders
***[[Acid-beta-glucosidase]]
** See: [[Metabolic Disorders]]
***[[Molecular_playground/beta_2_microglobulin|ß-2 Microglobulin]]
***[[HMG-CoA Reductase]]
***[[Molecular_Playground/Human_PPCA|Protective Protein/Cathepsin A (PPCA)]]
***[[Molecular_Playground/Human_Protective_Protein_Cathepsin_A|Protective Protein/Cathepsin A (PPCA) 2]]
***[[Bacterial thiolase|Thiolase]]
***[[Treatment_of_Gaucher_disease]]
***[[Molecular_Playground/Velaglucerase|Velaglucerase]]
***[[Disulfide Connectivity of Velaglucerase|Velaglucerase Disulfide Connectivity]]


**Schizophrenia, Bipolar Depression, Insomnia, and Anxiety Disorders
**Schizophrenia, Bipolar Depression, Insomnia, and Anxiety Disorders
Line 143: Line 80:
**Viral Infection
**Viral Infection
***[[Molecular_Playground/T7_RNA_Polymerase_%287_mer_int%29| T7 RNA Polymerase]]
***[[Molecular_Playground/T7_RNA_Polymerase_%287_mer_int%29| T7 RNA Polymerase]]
*** HIV
*** See: [[Human Immunodeficiency Virus]]
****[[User:Eric Martz/Molecular Playground/HIVDrug|HIV-1 Drug]]
****[[HIV-1 protease|HIV-1 Protease]]
****[[User:Tsung-Yi_Lin/Sandbox|HIV-1 Protease Analysis]]
****[[HIV-1 Gag]]
****[[1gwp|HIV-1 Gag N-terminal Domain]]
****[[HIV-1 Gag Recruitment of Tsg101 and the Viral Budding Process]]
****[[HIV-1 NEF]]
****[[Molecular_Playground/HIV_Protease_Inhibitor|HIV-1 Protease Inhibitor]]
****[[HIV-1_Subtype_C_Protease|HIV-1 Subtype C Protease]]
****[[Retroviral Integrase]]
****[[Reverse Transcriptase]]
****[[Tetherin]]
*** Influenza
*** Influenza
**** [[Avian Influenza Neuraminidase, Tamiflu and Relenza]]
*** See: [[Influenza]]
**** [[Avian Influenza Neuraminidase, Tamiflu and Relenza]]
**** H1N1 Sequence Analyses
****** [[User:Michael_Strong/H1N1|H1N1 Swine Flu Sequence Analysis]]
****** [[User:Michael_Strong/H1N1/MP1/MSA|H1N1 Swine Flu Multiple Sequence Alignment]]
****** [[User:Michael Strong/H1N1/MP2/MSA|H1N1 Sequence Alignment of MP2 Protein]]
****** [[User:Michael_Strong/H1N1/PB2|H1N1 Sequence Alignment of PB2 Protein]]
****** [[User:Michael_Strong/H1N1/PB1|H1N1 Sequence Alignment of PB1 Protein]]
****** [[User:Michael_Strong/H1N1/NS2/MSA|H1N1 Sequence Alignment of NS2 Protein]]
****** [[User:Michael_Strong/H1N1/PA|H1N1 Sequence Alignment of PA Protein]]
****** [[User:Michael_Strong/H1N1/HA|H1N1 Sequence Alignment of HA Protein]]
****** [[User:Michael_Strong/H1N1/NP|H1N1 Sequence Alignment of NP Protein]]
****** [[User:Michael_Strong/H1N1/NA|H1N1 Sequence Alignment of NA Protein]]
****** [[User:Michael_Strong/H1N1/MP|H1N1 Sequence Alignment of MP Protein]]
****** [[User:Michael_Strong/H1N1/NS|H1N1 Sequence Alignment of NS Protein]]
**** [[SAndbox_159|Hemagglutinins]]
**** [[Influenza hemagglutinin]]
**** [[Molecular_Playground/Influenza_A_M2_transmembrane_domain|Influenza A M2 Transmembrane Domain]]
**** [[Proton Channels]] featuring a morph of the M2 proton channel of influenza.
**** [[Molecular Playground/Tamiflu|Tamiflu]]
**** [[Molecular Playground/Relenza|Relenza]]
*** [[Herpes Simplex Virus Thymidine Kinase]]
*** [[Herpes Simplex Virus Thymidine Kinase]]
*** [[NS5B|RNA Dependent RNA Polymerase from Hepatitis C Virus]]
*** [[NS5B|RNA Dependent RNA Polymerase from Hepatitis C Virus]]
}}
}}

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

David Canner, Thomas J. Stout, Eran Hodis, Wayne Decatur, Alexander Berchansky